Diabetes Mellitus, Type 2 Clinical Trial
Objective: The main target of this study was to research the early changes of retrobulbar
and intrarenal hemodynamics, then to research the correlation between them in type 2
diabetes (T2DM) patients without diabetic kidney disease (DKD) and diabetic retinopathy
(DR).
Method: 35 T2DM patients (diabetes group) without vascular complications and 30 healthy
people (control group) were recruited to research the early changes of renal function,
retrobulbar and intrarenal hemodynamics, and then to research the correlation between them.
The primary endpoints were the intrarenal hemodynamic (bilateral kidney RI) in bilateral
interlobular renal arteries were evaluated using Doppler Sonographic; the secondary
endpoints were the retrobulbar hemodynamics RI in the bilateral central retinal artery
(CRA), posterior ciliary artery (PCA), and arteria ophthalmica (OA) were evaluated using
color doppler imaging (CDI); the tertiary endpoints were the biochemical endpoints:
blood-fat (TC, HDL-C, LDL-C, and TG), FPG, 2hPG, HbA1c, and renal function parameters (BUN,
Cr, and GFR); in addition, the albumin excrete rate (AER), urinary albumin/creatinine ratio
(UACR) were measured.
n/a
Observational Model: Case Control, Time Perspective: Retrospective
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