Diabetes Mellitus Type 2 Clinical Trial
Glucagon like peptides receptors expression in the stomach of diabetes type 2 Glucagon like
peptides (GLP-1, GLP-2), are hormones secreted by L cells located along the gastrointestinal
tract. These hormones are secreted after meals and have some roles in regulating the
digestion process, absorption, and sending signals to the brain that regulate food
consumption. GLP peptides affect peripheral targets and have an important homeostatic role.
GLP-1 decreases the circulatory glucose level and GLP-2 has trophic effects which enable
adequate intestine growth.
We aimed in our study to investigate the GLP-1 and GLP-2 receptor expression in different
zones of the stomach in diabetes type 2 patients. If there are differences, it might explain
the pathological gastric emptying in these patients.
Understanding the function of these peptides may lead to new therapeutic options for
diabetic patients with delayed gastric emptying.
Methods: 20 diabetes type 2 patients with symptoms that need upper endoscopy will be
included in the study and 20 controls aged 18-70 years. Patients with neurological disease
will be excluded. During esophagogastroduodenoscopy 3 biopsies will be taken from the
antrum, corpus and cardia. The biopsies will be stored in -70. After RNA extraction the GLP
receptors expression will established by real time PCR method. Patients with different
expression compared to control will undergo isotopic scan for gastric emptying.
n/a
Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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