Diabetes Complications Clinical Trial
Official title:
Neurotrophic Factors in Cerebrospinal Fluid in Diabetic Patients With Polyneuropathy
Background: The pathogenetic factors underlying development of diabetic polyneuropathy (DP)
remain unclear. Reduced neurotrophic stimulation has been proposed as a possible mechanism.
The neurotrophic factors IGF I and II, sCD-163, NGF, VEGF and BDNF are essential for
development and regeneration of the nervous system. In earlier studies reduced
concentrations of IGF-I and II in blood and reduced concentrations of NGF and BDNF in muscle
and skin biopsies have been found in patients with DP.
Purpose: Our purpose is to determine the concentration and biological activity of
Insulin-like Growth Factor I and II (IGF-I and II), soluble Cluster of Differentiation 163
(sCD-163), Nerve Growth Factor (NGF), Vascular Endothelial Growth Factor (VEGF) and
Brain-derived Neurotropic Factor (BDNF) in cerebrospinal fluid and in blood in patients with
diabetes and/or nerve disease (especially diabetic polyneuropathy) as well as in healthy
control subjects. We will furthermore relate the findings to peripheral nerve function. In
addition the composition of the cerebrospinal fluid will be analyzed using mass
spectrometry.
Hypothesis: We hypothesize that DP develops due to reduced concentration and biological
activity of neurotrophic factors. We expect the concentration of IGF-I and II, VEGF, NGF and
BDNF to be reduced in cerebrospinal fluid in patients with DP compared to diabetic patients
without damage to the nervous system and healthy control subjects.
Methods: Study subjects consists of patients from Department of Neurology and Department of
Department of Clinical Medicine (Endocrinology and Diabetes) Aarhus University Hospital,
Denmark, who are having a lumbar puncture performed.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03022721 -
Heidelberg Study on Diabetes and Complications
|
N/A | |
| Withdrawn |
NCT02580266 -
Blood/Urine Markers for Drug Discovery for Renal Disease in Diabetes
|
||
| Completed |
NCT02423434 -
Evaluation of Corneal Confocal Microscopy for the Identification and Prediction of Neuropathy in Type 1 Diabetes
|
||
| Completed |
NCT01695278 -
A Pilot Intervention Study of Health Coaching to Promote Diabetes Self-Care in the Community
|
Phase 3 | |
| Completed |
NCT03426566 -
Abnormal Plantar Pressure in Patients With Diabetes
|
||
| Completed |
NCT02588898 -
B-Vitamins and Polyneuropathy in Patients With Type 2 Diabetes
|
||
| Completed |
NCT00815178 -
Effects of Inspiratory Muscle Training on Type 2 Diabetes Mellitus Patients With Inspiratory Muscle Weakness
|
N/A | |
| Not yet recruiting |
NCT04537676 -
Patient Empowerment Study
|
||
| Terminated |
NCT02915263 -
The Efficacy Of Intravenous Immunoglobulin Therapy In Treatment Induced Neuropathy Of Diabetes
|
Phase 2 | |
| Completed |
NCT01929018 -
Collaborative-care Rehabilitation After Dysvascular Amputation
|
N/A | |
| Completed |
NCT03877523 -
Cocarnit Effects on Macrophages Polarization
|
N/A | |
| Completed |
NCT02947828 -
Polyneuropathy in Diabetes Mellitus Type 2
|
||
| Completed |
NCT02928939 -
Therapeutic Conflicts and Multimorbidity
|
||
| Recruiting |
NCT02275091 -
Children With Diabetes at Risk for Heart Disease.
|
||
| Terminated |
NCT00529204 -
Effects Of Exenatide On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Fatty Liver Disease
|
Phase 2 | |
| Not yet recruiting |
NCT05074849 -
Benefits of Insoles With Real-Time Alert and Foot Self-Care Education
|
N/A | |
| Completed |
NCT04963998 -
Safety and Efficacy Study of MedCu Wound Dressings
|
N/A | |
| Recruiting |
NCT06321029 -
Electronic Diabetes Tune-Up Group (eDTU) for African Americans
|
N/A | |
| Active, not recruiting |
NCT03620773 -
Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes
|
Phase 1/Phase 2 | |
| Completed |
NCT05231642 -
Individualised Postprandial Glucose Responses in Type 1 Diabetes
|
N/A |