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Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation

Depressive Disorder, Major Clinical Trial

Official title:
Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.1. (Pharmacological Manipulation)

Clinical Trial Summary

The study will investigate whether a nociceptin receptor antagonist will normalize neural and behavioral processes of approach/avoidance decision-making in unmedicated individuals with major depressive disorder (MDD) and anxiety disorders. More specifically, the study aims to investigate dysregulation within (1) corticostriatal-midbrain circuitry and (2) nociceptin/orphanin FQ peptide and the nociceptin receptor (NOPR).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05232032
Study type Interventional
Source Mclean Hospital
Contact Emma Palermo, BA
Phone 617-855-4412
Email ehpalermo@mclean.harvard.edu
Status Not yet recruiting
Phase Phase 2
Start date August 1, 2024
Completion date March 31, 2025
View Details
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