Depressive Disorder, Major Clinical Trial
Official title:
Memantine as an Adjunctive Agent to Reduce Neurocognitive Deficits Following Unilateral ECT for the Treatment of a Severe Major Depressive Episode
The purpose of this study is to determine whether taking the medication memantine reduces impairment of memory and attention associated with electroconvulsive therapy.
The primary objective of this study is to determine whether the novel NMDA antagonist
memantine, FDA approved for use in moderate to severe alzheimers dementia, may reduce the
neurocognitive deficits associated with right unilateral ECT treatments in patients receiving
ECT for a severe and relatively refractory Major Depressive episode.
Our hypothesis is that the use of an NMDA antagonist would reduce intracellular calcium
levels, and glutamatergic stimulation during ECT. This reduction in excitatory stimulation
during ECT would reduce hippocampal and prefrontal neuronal endangerment and dysfunction,
thereby reducing cognitive impairment associated with right unilateral ECT treatments. We
also hypothesize that ACTH and cortisol levels will correlate with neurocognitive impairment
in placebo treated subjects, but not in the memantine treated individuals.
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