Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients

Depression Clinical Trial

— RIHANNA  

Official title:

Development of a New Neuroimaging Method Aimed to Differentiate Mnesic Abilities of Alzheimer and Depressed Patients

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02840045
• Other study ID #: API/2014/51
• Status: Recruiting
• Phase: N/A
• First received: July 12, 2016
• Last updated: August 8, 2017
• Start date: February 20, 2015
• Est. completion date: August 20, 2018

Study information

• Verified date: August 2017
• Source: Centre Hospitalier Universitaire de Besancon
• Contact: Damien Gabriel, PhD
• Phone: 0033381219148
• Email: dgabriel[@]chu-besancon.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to use a new method to differentiate mnesic abilities of early alzheimer patients and patients with a depressive disorder.

This method is based on the recording of cerebral activity while patients listen to familiar, unfamiliar and newly-learned music.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: August 20, 2018
• Est. primary completion date: August 20, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Being right-handed

• recorded consent

• For Alzheimer patients: Mini Mental Status Examination (MMSE) score >= 18

• For patients with a depressive disorder : Major Depressive Disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM IV) and Montgomery-Asberg depression rating scale (MADRS) score >= 25

• For healthy controls : no cognitive deficit, MADRS score < 25, no depressive disorder according to DSM IV

Exclusion Criteria:

• Auditory deficit

• contraindication to a high-density electroencephalography exam

• refusal to participate in the study

Related Conditions & MeSH terms

• Alzheimer Disease
• Depression

Intervention

Device:
• high-density electroencephalography
Musical stimulation during electroencephalography recording

Locations

Country	Name	City	State
France	CHRU Besançon	Besancon	Franche-Comte

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Besancon

Country where clinical trial is conducted

France, 

References & Publications (1)

Gabriel D, Wong TC, Nicolier M, Giustiniani J, Mignot C, Noiret N, Monnin J, Magnin E, Pazart L, Moulin T, Haffen E, Vandel P. Don't forget the lyrics! Spatiotemporal dynamics of neural mechanisms spontaneously evoked by gaps of silence in familiar and newly learned songs. Neurobiol Learn Mem. 2016 Jul;132:18-28. doi: 10.1016/j.nlm.2016.04.011. Epub 2016 Apr 27. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Amplitude of event-related potentials	Measurements of the amplitude of event-related potentials with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs	day 1 for familiar and unfamiliar songs and day 14 for newly learned songs
Secondary	Spectral power	Measurements of the spectral power with electroencephalography at day one for familiar and unfamiliar songs and after 2 weeks for newly learned songs	day 1 for familiar and unfamiliar songs and day 14 for newly learned songs