Depression Clinical Trial
Official title:
Activation on Left Dorsolateral Prefrontal Cortex LDPC With Different Acupoint-Combinations for Depression: An fNIRS Study
This is a randomized, open-labelled study to study the effect of the different acupoints
combination under TCM treatment principles by fNIRS.
The investigator aim to recruited 36 depression subjects and go through 6 acupuncture
treatment sessions in 3 weeks. They will be divided into 2 groups by randomization. (Group A
n=18, Group B n=18) The participants will receive 2 acupuncture session per week for 3
consecutively weeks. In each treatment session, all subjects in both groups will receive the
same amount of needle insertion ( total 14 needles) , all needles will be retained for 30
minutes. The whole treatment will last for around 45 minutes. No sedation will be conducted.
Subjects in Group A will receive 14 needles based on the TCM theory "Soothing liver-qi
stagnation", all needles will be retained for 30 minutes. Acupoint combination: Taichong太衝
(LR 3), Ligou蠡沟 (LR 5), Zhongdu 中都(LR6), Xiguan膝關 (LR 7), Ququan曲泉 (LR 8), Zhangmen章門(LR13),
Qimen期門 (LR14).
Subjects in Group B will receive 14 needles based on the TCM theory "Soothing liver-qi
stagnation" and "Tonifying the heart and the spleen"and "Invigorating the Yang Qi", all
needles will be retained for 30 minutes. Acupoint combination: Taichong太衝 (LR 3), ,
Sanyinjiao 三陰交 (SP 6), Xuanzhong懸鐘 (GB 39), Shenmen 神門 (HT 7), Zusanli 足三里(ST 36), Baihui
百會(DU 20), Shenting神庭(DU24), Qihai 氣海(RN6), Guanyuan 關元(RN4). Teding Diancibo Pu
(abbreviation: TDP) "特定電磁波譜" will be applied to Group B immediately after the needle
insertion. This TDP device is a infra-red heat lamp which is commonly used by acupuncturists
and Chinese Medicine Practitioner as a therapeutic substitute for moxibustion. The procedure
will be lasted for 30 minutes in 30-40 cm above the specified acupoint Qihai 氣海(RN6) and
Guanyuan 關元(RN4).
Status | Recruiting |
Enrollment | 36 |
Est. completion date | April 2017 |
Est. primary completion date | April 2017 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: 1. Age between 18 and 65; 2. Primary diagnosis as moderate and moderate severe depression; 3. Patient Health Questionnaire Depression Self-test (PHQ-9) score 10-19. Exclusion Criteria: 1. Patients with primary diagnosis as Major Depressive Disorder, any history of psychosis or mania. 2. Conditions that may make it difficult to conclusively determine that depressive symptoms are the result of Depression and not some other condition: any form of substance abuse or dependence within the last 6 months, relevant medical conditions that may be the medical basis of a depression including epilepsy, history of an abnormal EEG, severe head trauma, or stroke. 3. Serious uncontrolled medical conditions [e.g. poorly controlled diabetes, severe congestive heart failure], or other medical conditions that have not been stable for at least 3 months; 4. Received Electroconvulsive therapy (ECT) in the past year. 5. Current active suicidal or self-injurious potential necessitating immediate treatment 6. Pregnant |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Hong Kong | School of Chinese Medicine, The University of Hong Kong | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
The University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change of Brain activation hemodynamic signals in 6 acupuncture sessions (concentration level of Oxygenated Hemoglobin (O2Hb) over the left dorsolateral prefrontal cortex (DLPFC) | Will be measured by a customized portal fNIRS device | 5 minutes before, during and 10 minutes after the 1st and the last (6th) acupuncture treatment session. | No |
Primary | Change of Brain activation hemodynamic signals in 6 acupuncture sessions (Deoxygenated Hemoglobin (HHb)) over the left dorsolateral prefrontal cortex (DLPFC) | Will be measured by a customized portal fNIRS device | 5 minutes before, during and 10 minutes after the 1st and the last (6th) acupuncture treatment session. | No |
Secondary | PHQ-9 | 1. Screening stage; 2. Before start of 1st treatment in Week 1; 3. Immediately after the 2nd treatment in Week 3;4. 1st week, 2nd week and 4th week after the last treatment, conducted by telephone | No |
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