Depression Clinical Trial
Official title:
The Effects of JNJ-39393406 on Psychometric Performance and Residual Depressive Symptoms in 80 Patients With Unipolar or Bipolar Depression: a Phase II Exploratory add-on Double Blind Placebo Controlled 2 Week Trial
To evaluate the effects of the nicotinic allosteric modulator JNJ-39393406 on psychometric performance and residual depressive symptoms in patients who have been diagnosed with unipolar and bipolar depression but currently DO NOT meet criteria for an episode of Major Depression or Manic Episode.
To evaluate the effects of the nicotinic allosteric modulator JNJ-39393406 on psychometric
performance and residual depressive symptoms in patients who have been diagnosed with
unipolar and bipolar depression but currently DO NOT meet criteria for an episode of Major
Depression or Manic Episode.
Hypothesis: Allosteric modulation of the a7nAChR with JNJ-39393406 improves psychometric
performance and residual depressive symptoms in patients with unipolar major depression
disorder (MDD) or bipolar depression (BPD).
Outcome measurements:
- BACS
- MADRS
- BNSS
- CGI-S- BP,
- Questionnaire on smoking urges (QSU) and time to the first cigarette after waking up in
the morning,
- Readiness for discharge scale.
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