Depression Clinical Trial
Official title:
The Effect of Duloxetine on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients
Primary tumor glioblastoma is the most common malignant brain. Standard treatment includes
biopsy or excision of the tumor in order to obtain a pathological diagnosis, and tumor mass
reduction. After the surgery patients are treated with radiation and Temodal. The most
common psychiatric symptom in this patient population is depression, valued at up to
approximately 50% in patients with glioma . Depression not only adversely affects the
quality of life of patients but also impairs the ability and cognitive function due to the
complex clinical course of patients with glioblastoma. There is a tendency to give Diagnosis
of depression in this patient population, due to a lack of awareness, knowledge and
literature on the subject. This study was designed to prospectively randomized, controlled,
double-blind study.
This method of recruitment - patients who undergo resection or biopsy of glioblastoma (newly
diagnosed glioblastoma), immediately after diagnosis, patients will receive an explanation
about the study and sign a consent form will enter research.
This study was designed to prospectively randomized, controlled, double-blind study.This
method of recruitment patients who undergo resection or biopsy of glioblastoma (newly
diagnosed glioblastoma), immediately after diagnosis, patients will receive an explanation
about the study and sign a consent form will enter research.
Patients who underwent resection or biopsy of glioblastoma (newly diagnosed glioblastoma),
will randomization ratio of 1: 1 by the pharmacist (by age, Karnofsky score, the degree of
tumor resection) two research groups:
Group # 1: consisting of 50 patients who will be treated immediately after diagnosis, 30 mg
Cymbalta morning for a week and then a dose exceeding 60 mg for 3 months.
Group # 2: will include 50 patients treated immediately after diagnosis placebo for 3
months.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
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