Depression Clinical Trial
Official title:
Feasibility of Implementing Mental Health Treatment in Routine Adult Sickle Cell Disease Care Using Online Cognitive Behavioral Therapy and a Mobile Technology-Based Intervention
Patients with sickle cell disease (SCD) experience significant depressive symptoms that
currently go unrecognized and under-treated. Further, depression in this patient population
has the potential to contribute to high health care utilization and poor disease outcomes;
however, there are currently no comparative effectiveness studies of evidenced-based mental
health treatments for depression in SCD.
The primary objective of this study is to test the effectiveness of an online computerized
cognitive behavioral therapy intervention to address psychological and behavioral needs of
patients with sickle cell disease, namely depression and pain symptoms. The investigators
will implement an existing computerized cognitive behavioral therapy (CCBT) program called
"Beating the Blues" into routine clinical care at the University of Pittsburgh Medical
Center (UPMC) Adult Sickle Cell Clinic to determine the effectiveness of this intervention
in decreasing depression and pain versus treatment as usual. Patients with significant
distress—depression and/or anxiety symptoms—will be randomized to either eight sessions of a
CCBT program and weekly follow-up with a care manager or treatment as usual where the
treating physician is notified of the patient's symptoms. The investigators will evaluate
patient acceptability, implementation and practicality of the online mental health
intervention through patient use of the site (frequency and duration of visits), qualitative
interviews, and surveys. The investigators hypothesize: 1) the CCBT will be an acceptable
mental health treatment for patients and easily integrated into routine clinical care; 2)
patients in the treatment arm will show a greater decrease in depression/anxiety symptoms
and average daily pain than patients in usual care.
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