Ketamine Use in Electroconvulsive Therapy

Status Withdrawn

Clinical Trial Summary

The purpose of this study is to determine whether combination of ketamine plus electroconvulsive therapy improves depressive symptoms decreasing cognitive side effects.

Clinical Trial Description

This study will compare the clinical response to brief pulse ECT with infusion of ketamine 0.5 mg/kg versus brief pulse electroconvulsive therapy with infusion of placebo (saline) in major depression. We also will compare levels of cognitive impairment among these groups, compare levels of quality of life among these groups, compare levels of BDNF among these groups. We also will study if levels of 25-hydroxyvitamin D are associated with cognitive impairment in subjects undergoing ECT. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Depression

Clinical Trial Details

NCT number	NCT02012335
Study type	Interventional
Source	Hospital de Clinicas de Porto Alegre
Contact
Status	Withdrawn
Phase	N/A
Start date	January 2014
Completion date	January 2016

View Details

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