Neuroimaging Predictors of Antidepressant Treatment Outcome

Status Withdrawn

Clinical Trial Summary

Current medical therapies for depression take weeks to achieve full efficacy, and are ineffective in many patients or cause intolerable side effects, emphasizing the need for a deeper understanding of depression and its treatment. Identifying early brain biomarkers of treatments responses seems necessary to improve antidepressant treatment outcome. In this study we aim to detect early brain responses to a fast acting antidepressant-like treatment administered intravenously during a Real-Time Neurofeedback functional magnetic resonance imaging (MRI) Task to predict antidepressant treatment outcome in depression. At completion of the neuroimaging task, participants will enter a placebo-controlled clinical trial with a selective serotonin reuptake inhibitor (SSRI).

Clinical Trial Description

n/a

Study Design

Intervention Model: Single Group Assignment, Masking: Single Blind (Subject)

Related Conditions & MeSH terms

Depression

Clinical Trial Details

NCT number	NCT02000726
Study type	Interventional
Source	University of Michigan
Contact
Status	Withdrawn
Phase	Phase 2
Start date	July 2013
Completion date	June 2014

View Details

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