Depression Clinical Trial
Official title:
The Nocebo Effect: a Prospective Study of Informed Consent as a Factor in the Prevalence of SSRI's Side Effects
In this study we invetigate the influence of the nocebo effect (as part of obtaining informed consent) on the prevalence of side-effects. The study is prospective, focusing on the connection between what the physicians says to the patient about side-effects to the frequency of these side effects during treatment period. We also inquire whether informing the patient about the existence of the nocebo effect influences the extent of phenomena.
In this study the investigators wish to inquire whether the nature of the explenation given
to the patient as part of informed consent has an effect on the prevalence of side-effects.
The study will take place in the out-patient clinic at the Shalvata Mental health Center.
Three arms are included:
1. 50 patients started on SSRI's will be updated about its common side effects
2. 50 patients started on SSRI's will be updated about its common side effects and will
receive an explenation on the nocebo effect
3. 50 patients started on SSRI's will receive an explenation on the nocebo effect, but
will not be updated about common side-effects. Nonetheless, they will be informed of
severe side-effects.
Following the prescription of an SSRI the subjects will we enter the follow-up phase of the
study. They will attend two follow-up meetings: 3 days after the initiation point and one
month after the starting point. During each meeting they will be asked to fill the
Antidepressant Side-Effect Checklist (ASEC)and the General Health Questionnaire (GHQ).
;
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
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