Dementia Clinical Trial
Official title:
Multimodal Imaging in Alzheimer's Disease and Other Neurodegenerative Diseases
The purpose of this study is to investigate whether markers of brain structure and function from MRI are associated with different levels of spatial orientation and gait parameters in people with mild cognitive impairment or dementia due to Alzheimer's disease when walking through a real world environment.
This is an experimental cross-sectional study which primarily aims at identifying
characteristic features of spatial disorientation among people with mild cognitive impairment
and dementia. The features of interest are motion and physiological related changes that
occur during instances of spatial disorientation, which will be derived from wearable
sensors.
Additionally, brain structure and functional connectivity changes associated with different
levels of spatial orientation and gait parameters will also be investigated through
resting-state functional imaging.
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