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Defect of Articular Cartilage clinical trials

View clinical trials related to Defect of Articular Cartilage.

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NCT ID: NCT02855073 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects

Start date: July 2014
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the effectiveness of ReJoinTM for the Knee Osteoarthritis patients with Cartilage Defects comparing to Sodium Hyaluronate Injection.

NCT ID: NCT02696876 Completed - Clinical trials for Osteoarthritis, Knee

Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair

AURA
Start date: January 2017
Phase: N/A
Study type: Interventional

This is a proof-of-concept study to determine the safety and efficacy of a novel device to increase the reparative capacity of the knee. The discovery of a resident population of mesenchymal stem cells (MSCs) within synovial fluid (SF) was the first description of this reparative cell population having direct access to superficial cartilage and joint structures. The ready access of SF MSC to cartilage and other joint tissues offers a novel strategy for joint repair. Current arthroscopic procedures result in the removal of all SF MSCs due to continuous irrigation throughout the procedure. The current study would benefit the patient by greatly increasing the reparative capacity of the joint by bolstering MSC numbers and retaining those MSCs within the joint after surgery. By accessing MSCs from the synovium it is anticipated that these cells would be entrapped/migrate into the marrow clot formed by microfracture of the sub-chondral bone. These MSCs would supplement those from the marrow and may result in faster, better quality repair.

NCT ID: NCT02659215 Active, not recruiting - Clinical trials for Defect of Articular Cartilage

HyaloFAST Trial for Repair of Articular Cartilage in the Knee

FastTRACK
Start date: December 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of Hyalofast® scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.

NCT ID: NCT02542566 Terminated - Clinical trials for Defect of Articular Cartilage

Protected Versus Early Weight Bearing Post Microfracture Surgery

Start date: January 21, 2015
Phase: N/A
Study type: Interventional

To test using a randomised control trial, whether conservative rehabilitation and protected weight bearing versus early weight bearing and accelerated rehabilitation affects patient outcomes post microfracture surgery of the knee.

NCT ID: NCT02539030 Active, not recruiting - Osteoarthritis Clinical Trials

Comparison of Efficacy and Safety of Microfracture and Modified Microfracture

Start date: February 2013
Phase: Phase 4
Study type: Interventional

This study was designed to evaluate the efficacy and safety of a modified microfracture using collagen, and to compare them with those of a simple microfracture to prove the non-inferiority of the modified microfracture using collagen in patients with cartilage defects in their knees.

NCT ID: NCT02537067 Active, not recruiting - Clinical trials for Defect of Articular Cartilage

Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle

Start date: January 2010
Phase: Phase 3
Study type: Interventional

The objective of this study is to evaluate the efficacy and safety of Chondron (Autologus Chondrocyte) in patients with cartilage defects in their ankle for 18 months

NCT ID: NCT02524509 Active, not recruiting - Clinical trials for Defect of Articular Cartilage

the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee

Start date: January 2012
Phase: Phase 4
Study type: Observational

The purpose of this study is to evaluate safety and efficacy of Chondron(autologous cultured Chondrocyte) by comparing between Chondron implantation and Microfracture.

NCT ID: NCT02519881 Recruiting - Clinical trials for Defect of Articular Cartilage

the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle

Start date: February 2014
Phase: Phase 4
Study type: Interventional

This study was designed to evaluate the efficacy and safety of a modified microfracture using collagen, and to compare them with those of a simple microfracture in patients with cartilage defects in their ankles.

NCT ID: NCT02203071 Completed - Clinical trials for Defect of Articular Cartilage

Comparison of BioCartilage Versus Marrow Stimulating Procedure for Cartilage Defects of the Knee

Start date: June 2014
Phase:
Study type: Observational

Subjects will be selected among the investigators' patient population who are already scheduled to receive a marrow stimulating procedure (MSP), with or without the addition of BioCartilage. During the surgical operation for MSP, a portion of the patient's blood is taken out and used to form a patch to cover a cartilage defect of the knee. Currently it is considered standard of care to either form the patch using only a portion of the patient's blood, or form the patch using a portion of the patient's blood combined with an FDA-approved augmentation such as BioCartilage. This study will collect outcomes data and MRI for patients that are undergoing MSP with and without BioCartilage augmentation, then compare the data between those who received BioCartilage and those who did not. The primary endpoint is to determine whether subjects receiving a marrow stimulating procedure (MSP) augmented with BioCartilage have improved outcomes (measured using quality of life indicators, functional outcomes, and MRI) compared to subjects who receive MSP without the use of BioCartilage.

NCT ID: NCT01670617 Active, not recruiting - Knee Injuries Clinical Trials

DeNovo NT Natural Tissue Graft Stratified Knee Study

Start date: March 2012
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the long-term relief of pain and return to function for patients receiving DeNovo NT for cartilage lesions in the knee. DeNovo NT is a marketed product and has been used in more than 7,500 patients over the last 7 years.