HIV Infection Clinical Trial
Official title:
CIDRZ 1236 - Community-based Evaluation of a Pilot PMTCT Project in Kafue District: Impact of HAART to Prevent Pediatric AIDS in Rural Zambia.
In this study, the investigators will assess the population effectiveness of using routine
HAART as a PMTCT strategy, through a community-based survey. The survey will be done in the
catchment areas of four health clinics in rural Zambia both before and after giving routine
ART in the clinics, so as to estimate population HIV-free survival among infants born in each
target community.
The investigators hypothesize that incorporation of routine ART into PMTCT will increase the
HIV-free survival of exposed infants to 75%.
The primary objective is to determine the incremental benefit of a routine ART strategy for
PMTCT on a population basis, when compared to short-course Zidovudine and single-dose
Nevirapine (the current PMTCT standard of care).
We will take advantage of planned implementation of a pilot project for routine ART across
four primary care centres in rural Zambia (Kafue District). Using a community-based survey
modeled after the Demographic and Health Survey, we will measure HIV-free survival among
children under two years of age in the catchment areas surrounding these pilot sites, both
before and after implementation of services. We will use before-after comparisons in each of
these four communities to better understand the incremental benefit of providing these
services.
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