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Dactinomycin Adverse Reaction clinical trials

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NCT ID: NCT04933344 Recruiting - Clinical trials for Bone and Joint Infection

Pharmacokinetics and Toxicodynamics of Daptomycin in Bone and Joint Infections

PKTOXDAP
Start date: June 15, 2021
Phase:
Study type: Observational

the aim of this study is to investigate the relationship between exposure to daptomycin and the occurrence of muscle toxicity or eosinophilic pneumonia in patients treated with daptomycin for bone and joint infection

NCT ID: NCT04414137 Recruiting - Clinical trials for Bone and Joint Infection

Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin

Start date: February 19, 2019
Phase:
Study type: Observational

Daptomycin is an antibiotic from the family of cyclic lipopeptides, bactericide, concentration-dependent. Its spectrum concerns Gram-positive bacteria. Since the authorization of daptomycin in 2006, cases of eosinophilic pneumonia and pulmonary eosinophilia associated with its use have been reported in Europe and worldwide. The purpose of this study is to describe the mechanism of occurrence of this AE with dapto; Prolonged exposure and accumulation at the alveolar level could potentially have a role. Better understanding the mechanisms of appearance of this AE would provide predictive elements making it possible to limit the occurrence of this AE in the future