Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin

Bone and Joint Infection Clinical Trial

Official title: Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin

Status Recruiting

Clinical Trial Summary

Daptomycin is an antibiotic from the family of cyclic lipopeptides, bactericide, concentration-dependent. Its spectrum concerns Gram-positive bacteria. Since the authorization of daptomycin in 2006, cases of eosinophilic pneumonia and pulmonary eosinophilia associated with its use have been reported in Europe and worldwide. The purpose of this study is to describe the mechanism of occurrence of this AE with dapto; Prolonged exposure and accumulation at the alveolar level could potentially have a role. Better understanding the mechanisms of appearance of this AE would provide predictive elements making it possible to limit the occurrence of this AE in the future

Clinical Trial Description

Daptomycin is an antibiotic from the family of cyclic lipopeptides, bactericide, concentration-dependent. Its spectrum concerns Gram-positive bacteria. The Infectious Diseases Society of America recommends the use of daptomycin 6 mg / kg / day in the second-line treatment of IOA on staphylococcal but also enterococcal prostheses, as an alternative to vancomycin and linezolid. In case of renal failure, daptomycin is often considered as a good therapeutic alternative to glycopeptides. Since the authorization of daptomycin in 2006, cases of eosinophilic pneumonia and pulmonary eosinophilia associated with its use have been reported in Europe and worldwide. Although a large proportion of cases have been reported in patients receiving daptomycin in unapproved indications, the use of daptomycin in authorized indications has also been associated with this risk. The dosage of daptomycin makes it possible to evaluate its effectiveness and prevent the occurrence of a overdose, provider of side effects. The purpose of this study is to describe the mechanism of occurrence of this AE with dapto; Prolonged exposure and accumulation at the alveolar level could potentially have a role. Better understanding the mechanisms of appearance of this AE would provide predictive elements making it possible to limit the occurrence of this AE in the future ;

Related Conditions & MeSH terms

• Bone and Joint Infection
• Dactinomycin Adverse Reaction
• Pneumonia
• Pulmonary Eosinophilia

• NCT number: NCT04414137
• Study type: Observational
• Source: Hospices Civils de Lyon
• Contact: Eugénie Mabrut, CRA
• Phone: 04 26 73 29 38
• Email: eugenie.mabrut@chu-lyon.fr
• Status: Recruiting
• Start date: February 19, 2019
• Completion date: September 1, 2021