Cushing's Syndrome Clinical Trial
Official title:
An Open-label Study of the Efficacy and Safety of CORLUX (Mifepristone) in the Treatment of the Signs and Symptoms of Endogenous Cushing's Syndrome
Patients will receive Corlux (mifepristone) daily for up to 24 weeks. Assessments of the signs and symptoms of Cushing's syndrome will be obtained.
Cushing's syndrome is a relatively rare disorder caused by prolonged exposure to high levels
of the glucocorticoid hormone cortisol. Cushing's syndrome may result from elevated
endogenous or exogenous sources of cortisol. Endogenous Cushing's syndrome resulting from
cortisol overproduction by the adrenal glands is the subject of this protocol. Patients with
exogenous Cushing's syndrome, which develops as a side effect of chronic administration of
high doses of glucocorticoids, are not eligible for enrollment in this study.
This will evaluate the safety and efficacy of mifepristone for treatment of the signs and
symptoms of hypercortisolemia in patients with endogenous Cushing's syndrome from
ACTH-dependent or adrenal disorders.
The study will enroll subjects for whom the investigator has determined that medical
treatment of endogenous hypercortisolemia is needed. Medical treatment may be intended to
treat the effects of persistent or recurrent hypercortisolemia after surgery and/or
radiation for Cushing's syndrome, to bridge the period of time for radiation to become
effective, or when surgery is not feasible.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02468193 -
Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome
|
Phase 2 | |
| Recruiting |
NCT00457587 -
Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma
|
||
| Completed |
NCT00006278 -
Study of Cushing's Syndrome Not Related to ACTH Production
|
N/A | |
| Completed |
NCT00361777 -
Diagnostic Performance of Screening Tests for Cushing s Syndrome
|
||
| Completed |
NCT03606408 -
Roll-over Study in Patients With Endogenous Cushing's Syndrome for LCI699
|
Phase 2 | |
| Completed |
NCT02663609 -
Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome
|
||
| Recruiting |
NCT01504555 -
Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome?
|
Phase 3 | |
| Active, not recruiting |
NCT00004343 -
Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome
|
N/A | |
| Completed |
NCT02922257 -
Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery
|
||
| Completed |
NCT01371565 -
Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome
|
Phase 3 | |
| Terminated |
NCT00422201 -
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion
|
Phase 2 | |
| Completed |
NCT00001180 -
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency
|
N/A | |
| Completed |
NCT02804750 -
Study to Evaluate CORT125134 in Participants With Cushing's Syndrome
|
Phase 2 | |
| Completed |
NCT00936741 -
An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome
|
Phase 3 | |
| Recruiting |
NCT00004334 -
Study of Depression, Peptides, and Steroids in Cushing's Syndrome
|
N/A | |
| Completed |
NCT03817840 -
Novel Mediators of the Lipodystrophy and Metabolic Consequences of Cushing's Disease
|
||
| Completed |
NCT01959711 -
Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy
|
Phase 4 | |
| Completed |
NCT05633953 -
Osilodrostat for the Treatment of Non-Cushing's Disease Cushing's Syndrome
|
||
| Completed |
NCT02889224 -
In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in Man
|
N/A | |
| Terminated |
NCT00796783 -
A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia
|
N/A |