Cushing's Syndrome Clinical Trial
Official title:
In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in Man
Working hypothesis: the interactions between the endogenous endocannabinoïds (ECS) - and
cortisol, the end product of the Hypothalamo-Pituitary-Adrenal (HPA) axis may play a role in
the pathophysiology of Cushing's syndrome.
The investigators speculate that:
- acute or chronic variations in plasma cortisol may induce changes in the activity of the
ECS
- that there is a circadian rhythm of the ECS driven by the rythm of plasma cortisol
The study aim to identify the relationship between the ECS and the HPA axis in humans with a
main objective to assess if Cushing's syndrome induces changes in the ECS activity.
For this purpose:
1. the investigors will compare plasma levels of ECS between obese controls and patients
with Cushing's syndrome
2. the investigors will compare plasma levels of ECS in patients with Cushing's syndrome
before and immediately after curative surgery
3. the investigors will compare plasma levels of ECS in patients with hypoadrenalism before
and after the intake of substitutive doses of hydrocortisone
4. the investigors will evaluate the plasma levels of ECS during a short synacthen test in
healthy subjects.
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