HIV Infections Clinical Trial
Official title:
Trial for the Optimal Timing of HIV Therapy After Cryptococcal Meningitis
The Cryptococcal Optimal ART Timing (COAT) trial seeks to determine after cryptococcal meningitis (CM) whether early initiation of antiretroviral therapy (ART) prior to hospital discharge results in superior survival compared to standard initiation of ART started as an outpatient.
After 7-11 days of amphotericin B therapy, subjects will be randomized in a 1:1 allocation
to:
- Early initiation of ART (Experimental Group) = ART initiated within 48 hours after study
entry, OR
- Standard initiation of ART (Control Group) = ART at >=4 weeks after study entry
HIV therapy will be with efavirenz plus nucleoside backbone per national guidelines for first
line therapy.
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