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Cryopreservation clinical trials

View clinical trials related to Cryopreservation.

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NCT ID: NCT06448000 Completed - Healthy Clinical Trials

Effect of Long-time Human Sperm Storage in Liquid Nitrogen on Semen Parameters

CRYOFERT
Start date: January 2010
Phase:
Study type: Observational

Sperm cryopreservation is an essential tool for men fertility preservation in the context of gonadotoxic treatments or/and pathologies such as cancers, gamete donation and ART. Nevertheless, it is validated that the freezing and thawing procedures affect sperm parameters and in particular motility. It is therefore essential to determine the impact of storage time on motility and particularly the number of progressive motile spermatozoa which will determine the choice of ART technique. However, few studies have analyzed the impact of storage time in liquid nitrogen and no study over a long period on human spermatozoa and their use in ART. The aim of this study is to assess the impact of long-time storage, from 2 to 12 years, in liquid nitrogen on standard semen parameters, notably motility.

NCT ID: NCT06261658 Recruiting - Infertility, Female Clinical Trials

Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma

TESOVA2022
Start date: March 1, 2024
Phase: N/A
Study type: Interventional

The study is aimed to evaluate the effects of intraovarian injection of autologous Platelet-enriched Autologous Plasma on the outcomes of orthotopic transplantation of cryopreserved ovarian tissue.

NCT ID: NCT04487639 Completed - Fertility Clinical Trials

Presence of SARS-CoV-2 (COVID-19) in Semen: Impact on Fertility Preservation in Male Oncological Patients ?

FERTICOVID
Start date: July 10, 2020
Phase: N/A
Study type: Interventional

During the COVID-19 pandemic, the French Agency of Biomedicine has recommended maintaining fertility preservation for patients requiring immediate oncological treatments exhibiting gonadotoxic effects. However, no study has examined the presence of SARS-CoV-2 in sperm from cancer patients. This study aims therefore to detect the presence of SARS-CoV-2, specifically in the seminal fluid and the spermatozoa fractions of cancer patient semen. The investigators will determine if the virus presence in sperm is associated with its presence in the nasal swabs, COVID symptoms, specific serological profiles and particular oncological pathologies/treatments.

NCT ID: NCT04011813 Completed - Cryopreservation Clinical Trials

Hypotaurine Supplementation Benefits in Cryopreservation

HYPOTAURINE
Start date: May 1, 2014
Phase:
Study type: Observational

Although it is widely used, slow freezing can induce strong functional and nuclear spermatic alterations reducing the chances of pregnancy. The study objective is to determinate the effects of the combination of hypotaurine supplementation and spermatozoa selection by Density Gradient Centrifugation (DGC) on human sperm functions and DNA quality during a freezing-thawing cycle.

NCT ID: NCT03913208 Recruiting - Infertility Clinical Trials

Priority to Cryopreservation Strategy (PCS) in IVF-ICSI Cycles

PCS
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

This multicentre randomized controlled trial will be done to evaluate a new strategy in IVF-ICSI practice that gives that priority to freeze for the embryos and goes to fresh embryo transfer only if at least one set of same quality embryos is available for cryopreservation.

NCT ID: NCT03153436 Completed - Human Clinical Trials

The Effect of In-vitro Myoinositol Supplementation of Human Sperm on the Outcome of Cryopreservation

Start date: August 28, 2016
Phase: Phase 1/Phase 2
Study type: Interventional

The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

NCT ID: NCT02687880 Withdrawn - Infertility Clinical Trials

Testicular Tissue Cryopreservation for Fertility Preservation in Male Patients Facing Infertility-causing Diseases or Treatment Regimens

Start date: December 30, 2018
Phase:
Study type: Observational

Many chemotherapy and radiation-containing regimens for cancer or prior to bone marrow transplantation can cause sterility in children and young adults. In addition, some human disease conditions (e.g., Klinefelter's) are associated with infertility. Semen cryopreservation is available as a fertility-preserving option for post pubertal boys and adult men, but many do not take advantage of this option due in part to lack of information, illness, and/or time constraints relative to their treatment plan. Currently, no fertility-preserving options are available for prepubescent boys who are not yet producing sperm. The primary objective of the proposed study is to 1) Optimize techniques for cryopreserving testicular tissue, 2) Assess malignant contamination in testicular tissues and 3) develop methods to enrich spermatogonial stem cells and remove malignant contamination from testicular tissue. In addition, this study will process and cryopreserve tissue and/or cells for participating patients as a resource for future elective procedures to attempt fertility restoration.

NCT ID: NCT02032797 Completed - Embryo Implantation Clinical Trials

Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved(Frozen)-Thawed Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone.

PROFETA-5
Start date: November 2012
Phase: Phase 4
Study type: Interventional

The aim of the study is to determine whether 5 or 7 days of progesterone supplementation before transfer of a day 5 cryopreserved thawed embryos in an artificial cycle results in a significant higher pregnancy rate.

NCT ID: NCT00521443 Completed - Cryopreservation Clinical Trials

Cryosurvival of Embryos From Dysmorphic Oocytes

Start date: n/a
Phase: N/A
Study type: Observational

Various morphological abnormalities of human oocytes were reported to detrimentally affect embryo development. We observed development of frozen thawed embryos derived from oocytes with normal or abnormal morphological features to the blastocyst stage. Cytoplasmic abnormalities of the oocytes were found to negatively affect cryosurvival potential of the embryos.