Craniopharyngioma Clinical Trial
Official title:
The Effect of GLP-1 Agonist in Patients With Hypothalamic Obesity: Prospective, Pilot Study
GLP-1 analogs are used as agents in the existing treatment of obesity. However, there are lack of previous reports on the effectiveness and role of GLP-1 analogs in the development of obesity traits in patients with functionally impaired hypothalamus. With this preliminary study, the investigators would explore the role of GLP-1 analogues to identify eating behavioral pathology subtype differences in the therapeutic efficacy of GLP-1 analogues in hypothalamic obesity patients. This will allow us to identify the role of specific nuclei which could be the pathogenesis of hypothalamic obesity. Our hypotheses: GLP-1 analogs will effectively induce weight loss in patients with hypothalamic obesity, and different subtypes of hypothalamic obesity will respond differently to GLP-1 analogs.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | March 8, 2024 |
Est. primary completion date | February 8, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 19 Years and older |
Eligibility | Inclusion Criteria: - Patients diagnosed with a hypothalamic tumor and treated surgically with confirmed hypothalamic damage - 19 years of age or older - Have a body mass index of at least 27 and less than 30 (27=BMI<30) and one or more confirmed weight-related medical conditions, or a body mass index of 30 or greater (BMI=30). - Voluntarily agreed to participate in the study after receiving a full explanation of the study. Exclusion Criteria: - Unable to fully understand the instructions for participation in the study or unable to give voluntary consent. - Presence or history of a medical condition or disease that, in the opinion of the investigator, would make it difficult for the patient to participate fully for the duration of the study or to interpret the results of the study - Taking medications that may affect weight, except for hormone replacement therapy, in the last 6 months - non-primary tumor patient - Diagnosis of severe renal dysfunction, liver dysfunction, or thyroid disease among other underlying conditions |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Seoul National University Hospital | Seoul | Jongno-gu |
Lead Sponsor | Collaborator |
---|---|
Seoul National University Hospital |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in weight | 3 month |
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