Other Clinical Trial - Pulmozyme to Improve COVID-19 ARDS Outcomes

Status Recruiting

Clinical Trial Summary

This is a randomized double-blind placebo-controlled Phase II trial of recombinant human deoxyribonuclease I (rhDNase I) - Pulmozyme - in mechanically ventilated patients with COVID-19 pneumonia. Patients admitted to the ICU with severe COVID-19 pneumonia who require mechanical ventilation will be invited to participate in this study. Potential subjects will be identified from medical record review or from direct contact with physicians. Investigators will check medical history and confirm eligibility. Informed consent will be obtained from either the patient or designated healthcare proxy. 60 subjects will be enrolled. After obtaining informed consent, patients will be randomized 2:1 to Pulmozyme 2.5 mg BID for up to 28 days or until they are no longer receiving mechanical ventilation, whichever is sooner plus standard of care vs. placebo normal saline 2.5 ml plus standard of care.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

COVID

Clinical Trial Details

NCT number	NCT04402944
Study type	Interventional
Source	Boston Children's Hospital
Contact	Robert Fowler
Phone	6173551834
Email	robert.fowler@childrens.harvard.edu
Status	Recruiting
Phase	Phase 2
Start date	July 5, 2020
Completion date	December 31, 2021

View Details

See also
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