Resonance Breathing Training for Long Covid-related Myocardial Injury

Long COVID Clinical Trial

Official title:

An Investigation of the Efficacy of Resonance Breathing Training in the Rehabilitation of Patients With Long Covid-related Myocardial Injury

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06379672
• Other study ID #: 2023[No.193]
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 25, 2024
• Est. completion date: September 5, 2024

Study information

• Verified date: April 2024
• Source: Chengdu Sport University
• Contact: Rui Li
• Phone: 17711524016
• Email: wp100331[@]cdsu.edu.cn
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

An investigation of the efficacy of resonance breathing training in the rehabilitation of patients with Long covid-related myocardial injury

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 70
• Est. completion date: September 5, 2024
• Est. primary completion date: August 25, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

1. Age between 18 and 60 years;

2. According to the WHO definition: one or more systemic involvement present 3 months after the diagnosis of a new crown infection, and at least 2 of these months cannot be explained by other diseases

3. 2D-STE suggestive of GLSAVG: -17% = men = -10%, -18% = women = -10%;

4. Consent for enrollment based on the degree of myocardial injury, as diagnosed by a clinician;

5. Signing the informed consent form with the consent of the patient or his/her family members

Exclusion Criteria:

• (1) Previous history of coronary atherosclerotic heart disease and heart failure; (2) Combination of severe arrhythmia or cardiogenic shock; (3) Combination of severe hypertension, hypertrophic cardiomyopathy, valvular disease of moderate or higher grade, acute myocarditis or pericarditis; (4) Combination of any disease that severely affects limb movement, such as musculoskeletal system disease or severe hepatic or renal insufficiency; (5) Combination of progressive malignant tumors, infectious diseases, bleeding disorders, autoimmune diseases, etc; Those who have serious mental illness and are unable to cooperate

Related Conditions & MeSH terms

• Long COVID
• Myocardial Injury
• Wounds and Injuries

Intervention

Other:
• Resonance breathing
Resonant breathing was used on the subjects, using nasal inhalation and oral exhalation, for a total of 12 weeks.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Chengdu Sport University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	New YorkHeart Association (NYHA)	The scale is divided into four levels; Grade 1 is unrestricted activity. Daily physical activity does not cause significant shortness of breath, fatigue or palpitations Grade 2 is a mild limitation of activity. Asymptomatic at rest, daily activities may cause significant shortness of breath, fatigue or palpitations Grade 3 is marked limitation of activity. May be asymptomatic at rest, but may cause significant shortness of breath, fatigue, or palpitations with less than daily activity.; Grade 4 is symptomatic at rest, with discomfort associated with any physical activity. Class IVa for those who can move around indoors or at the bedside without intravenous drug administration; Class IVb for those who cannot get out of bed and require intravenous drug administration.	12weeks
Primary	left ventricle global longitudinal strain, LVGLS	The magnitude of overall longitudinal myocardial strain in the left ventricle on two-dimensional speckle tracking echocardiograms as an average of the peak longitudinal strain in all myocardial segments. The normal range is (-25% to -17%) in men and (-25% to -18%) in women.	12weeks
Secondary	hypertension	Blood pressure included both systolic and diastolic blood pressure and was observed before and after the intervention for any reduction in blood pressure.	12weeks
Secondary	Average heart rate	One-minute average heart rate (at rest).	12weeks