Cluster-Randomized Trial of Air Filtration and Ventilation to Reduce Covid19 Spread in Homes

Covid19 Clinical Trial

Official title:

A Cluster-randomized Controlled Trial of Air Filtration and Ventilation Improvements to Reduce SARS CoV 2 Transmission Among Household Contacts

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT05777720
• Other study ID #: 55479
• Secondary ID: 5T32AI052073-17
• Status: Enrolling by invitation
• Phase: N/A
• Start date: January 30, 2023
• Est. completion date: December 31, 2024

Study information

• Verified date: May 2024
• Source: Stanford University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Investigators are evaluating whether an intervention consisting of box-fans with MERV 16 filters ("filtration fans") and recommendations for improving ventilation in the home can reduce secondary spread of Covid19 from an index case to susceptible contacts within the home.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 200
• Est. completion date: December 31, 2024
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Household members live in a shared space (apartment, home) with others (as opposed to renting single rooms in a shared space, for example)

• At least 3 other people live in the household aside from index case

Exclusion Criteria:

• If index case test positive day was over 2 days prior

• If half or more household members are thought to be infected already

• If household has fewer than 3 contacts interested in participating in the study

• If fewer than 3 contacts are expected to be present in the house for a majority of the following 7 days

Related Conditions & MeSH terms

• COVID-19
• Covid19

Intervention

Device:
• Filtration Fan
Investigators are using box fans with attached MERV16 filters, a design that has been tested and published in the scientific literature.

Behavioral:
• Safe-home pamphlet
The pamphlet has information on how the filtration fans work through visual images; and images of ventilation improvements in the home through opening windows.
• Mid-week phone call
On day 3-4 of the study, the study coordinator assigned to the house will call and check in regarding the filtration fan usage and remind families about the importance of filtration and ventilation.

Locations

Country	Name	City	State
United States	San Mateo Medical Center	San Mateo	California
United States	Stanford University Medical Center	Stanford	California

Sponsors (2)

Lead Sponsor	Collaborator
Stanford University	National Institute of Allergy and Infectious Diseases (NIAID)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of Covid19	Investigators will measure the incidence of Covid19 in susceptible contacts on day 7.	7th day since enrollment in the trial
Secondary	Incidence of new upper respiratory symptoms	Investigators will measure reported new upper respiratory symptoms in susceptible contacts.	7th day since enrollment in the trial
Secondary	Average CO2 levels	Investigators will measure 7 day average CO2 levels in the home (measured in parts per million)	7 days