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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05706441
Other study ID # 2023-0017
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 11, 2023
Est. completion date March 30, 2023

Study information

Verified date January 2023
Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The goal of this observational study is to learn about the function of lung and diaphragm ultrasound during weaning from mechanical ventilation in COVID-19 patients. The aim of this study was that the lung ultrasound score and diaphragm muscle mobility could be a potential predictive factor of weaning success.


Recruitment information / eligibility

Status Completed
Enrollment 35
Est. completion date March 30, 2023
Est. primary completion date March 30, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - age > 18 years, - critically ill patients with COVID-19 (defined as those requiring mechanical ventilation due to respiratory failure), and eligible for their first SBT according to the attending physician's judgement that the underlying disease which led to intubation had sufficiently resolved. Exclusion Criteria: - patients with previous cardiothoracic surgery or pleurodesis and patients who presented with stridor (due to upper airway involvement) as a cause of extubation failure - neuromuscular disease

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Point-of-Care Ultrasound
Ultrasonographic scans of the lung and right hemidiaphragm were acquired after 30 min from the beginning of the SBT, or immediately before reconnecting the patient to the ventilator in the case of SBT failure occurring before

Locations

Country Name City State
China The Second Affiliated Hospital of Zhejiang University anesthesiology department Hangzhou Zhejiang

Sponsors (1)

Lead Sponsor Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary The primary end-point was to verify the lung and diaphragm ultrasound evaluation if the predicts weaning success/failure from mechanical ventilation Weaning failure was defined as failure to pass the spontaneous-breathing trial or the need for re-intubation within 48 h following extubation spontaneous-breathing trial started until 48 hours following extubation
Secondary The secondary outcome was to verify the predictive value of the traditional weaning parameters Weaning failure was defined as failure to pass the spontaneous-breathing trial or the need for re-intubation within 48 h following extubation spontaneous-breathing trial started until 48 hours following extubation
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