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COVID-19 Genomic Sequencing for Nosocomial Outbreak Investigations — NOSO-COVID  

COVID-19 Clinical Trial

Official title:
On-Demand Point-of-Care SARS-CoV-2 Genomic Sequencing to Support Nosocomial Outbreak Investigations: A Prospective Molecular Epidemiology Study in Montreal

Clinical Trial Summary

This is a tertiary care hospital-based prospective molecular epidemiology study in Montreal, Canada. When nosocomial transmission was suspected by local infection control teams' investigations, SARS-CoV-2 viral genomic sequencing was performed locally for all putative outbreak cases and contemporary controls. Molecular and conventional epidemiology data were confronted in real time to improve understanding of COVID-19 transmission and reinforce or adapt prevention measures.

Clinical Trial Description

This study will include infected healthcare workers (HCW) and patients for whom a nosocomial infection in CHUM is suspected. The CHUM laboratory is responsible for COVID-19 diagnostic testing in all eligible HCW and patients. After initial diagnosis on standard PCR testing, samples are maintained at -80. Viral RNA is extracted and next-generation sequencing of the viral genome is performed using Nanopore long read sequencing platform. Preliminary data suggest that SARS-CoV-2 has a "molecular clock" of 2 single nucleotide polymorphism (SNP) per month. The analysis and between-isolate comparaison of those SNP among epidemiologically related cases will allow to support or refute the hypothesis of person to person nosocomial transmission. All infected patients will be matched 1:1 with contemporary community cases to provide a viral genome back catalog and better contextualize molecular epidemiology analyses. Molecular clusters will be reported to infection prevention and control teams and resulting interventions will be monitored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05411562
Study type Observational
Source Centre hospitalier de l'Université de Montréal (CHUM)
Contact Simon Grandjean Lapierre, MD MSc FRCPC
Phone 514-890-8000
Email sgrandjeanlapierre@gmail.com
Status Recruiting
Phase
Start date November 9, 2020
Completion date December 31, 2023
View Details
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