Prognosis of Geriatric Patients 1 Year After Hospitalization for COVID-19

COVID-19 Clinical Trial

— PROVID-Ger  

Official title:

Prognosis of Geriatric Patients 1 Year After Hospitalization for COVID-19

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05261061
• Other study ID #: APHP211505
• Secondary ID: IDRCB 2021-A0268
• Status: Not yet recruiting
• Start date: July 2022
• Est. completion date: December 2022

Study information

• Verified date: June 2022
• Source: Assistance Publique - Hôpitaux de Paris
• Contact: Hélène VALLET, MD, PhD
• Phone: +33149282042
• Email: Helene.vallet[@]aphp.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Old patients hospitalized in Acute Geriatric Units are characterize by advanced age, frailty, high number of comorbidities, cognitive impairment and loss of functional autonomy. Although, intra-hospital mortality in geriatric population (out of COVID) is low (6%) the long-term prognosis is often worse (30 to 60% of loss of autonomy and 30% of one-year mortality among hospital survivors). For geriatric patients with COVID19, intra-hospital mortality is higher than in younger Covid patients (1), but also higher than in geriatric patients outside the Covid context (30 vs 6% (2, 3)). Our hypothesis is that geriatric patients surviving hospitalization for COVID-19 have a worse vital and functional prognosis at 12 months than geriatric patients surviving hospitalization for another medical reason.

Description:

Old patients hospitalized in Acute Geriatric Units are characterize by advanced age (average 85 years), frailty, high number of comorbidities, cognitive impairment and loss of functional autonomy.These particular state leads to multiple decompensations and the reason for initial hospitalization is often only the "tip of the iceberg". Although, intra-hospital mortality in geriatric population (out of COVID) is low (6%) the long-term prognosis is often worse (30 to 60% of loss of autonomy and 30% of one-year mortality among hospital survivors). For geriatric patients with COVID19, intra-hospital mortality is higher than in younger Covid patients (1), but also higher than in geriatric patients outside the Covid context (30 vs 6% (2, 3)). This excess mortality is all the more surprising as these patients seem to have fewer comorbidities than those usually hospitalized in acute geriatric units. Our hypothesis is that geriatric patients surviving hospitalization for COVID-19 have a worse vital and functional prognosis at 12 months than geriatric patients surviving hospitalization for another medical reason.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 1000
• Est. completion date: December 2022
• Est. primary completion date: December 2022
• Gender: All
• Age group: 75 Years and older

Eligibility

Inclusion Criteria:

• Age >=75 years
• Hospitalized for medical reason in acute geriatric unit
• Alive at hospital discharge

Exclusion Criteria:

• Patients hospitalized for surgical reason
• Patients under legal protection
• Patient refusal

Related Conditions & MeSH terms

• COVID-19

Locations

Country	Name	City	State
France	Service de gériatrie, Hôpital Saint Antoine	Paris

Sponsors (1)

Lead Sponsor	Collaborator
Assistance Publique - Hôpitaux de Paris

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	One-year mortality		1 year
Secondary	Activity of daily living (ADL) at 1 year		1 year
Secondary	SF-12 at one year	Quality of life	1 year
Secondary	Clinical Frailty Scale (CFS) at one year		1 year
Secondary	rehospitalization at one year		1 year