THE EFFECT OF LIFESTYLE ON THE PROGRESS OF COVID 19

COVID-19 Clinical Trial

Official title: LIFE STYLE BEFORE COVID 19 INFECTION IMPACT ON THE PROGRESS OF COVID 19

Status Active, not recruiting

Clinical Trial Summary

THE EFFECT OF LIFESTYLE ON THE PROGRESS OF COVID 19 INFECTION

The development of COVID 19 disease depends on the interaction with the immunity of the host. The immune response of the host is related to age, gender, nutrition, sleep and physical activity. Our study in Fatih Sultan Mehmet Training and Research Hospital; Between 31 January-31 May 2021,positive COVID 19 PCR test was performed with 66 patients over the age of 50, who received inpatient treatment. Demographic data of the patients, length of hospitalization, alcohol/tobacco use, BMI, comorbidities, regular use medication or not, thorax CT findings, place of discharge after treatment, laboratory parameters were recorded at hospitalization and discharge.

To evaluate the pre-infection lifestyle; physical activity, nutrition and sleep habits were questioned.

According to the PSQS (Pittsburg Sleep Quality Scale) although the increase in discharged lymphocyte measurements compared to the first hospitalization of the patients in the good and bad sleep groups was significant, there was no significant difference between the groups. In the evaluation between the groups, the increase in the NLR value at the first hospitalization was significant in the bad sleep group compared to the good sleep group. There was no difference between the groups in terms of NLR.

According to the MNA(Mini Nutritional Assessment)scale ;the increase in the discharge lymphocyte value of the groups compared to the value at the first hospitalization was significant. The increases in the discharge lymphocyte measurements of the patients compared to the first hospitalization were significant between the groups (p<0.05). The increase in discharge lymphocyte values in patients at risk of malnutrition compared to the first hospitalization was higher than in patients with malnutrition (p<0.05). The decrease in discharge NLR values compared to the first hospitalization was significant in the group under normal nutrition and malnutrition risk. The difference between the first hospitalization PLT (Platelet)measurements of the groups according to the MNA scale was significant.

According to the International Brief Physical Activity Survey; the increase in the discharge lymphocyte value of the inactive, minimally active and very active groups was significant compared to the first hospitalization. A significant difference was found between the PLT measurements between the groups (p<0.05). PLT measurements of very active cases were higher than those of minimally active cases (p<0.05).

In this study, in which we examined the effects of lifestyle before the diagnosis of COVID 19 on the course of COVID 19, we observed that there is no need for intensive care in patients who are well fed, have good sleep quality and are physically active.

Clinical Trial Description

Our study in Fatih Sultan Mehmet Training and Research Hospital; It was conducted prospectively on 31 January - 31 May 2021:

Inclusion criteria:

Patients over 50 years of age, Who were hospitalized in the pandemic ward Patients with positive COVID 19 pcr test and were taken into ethical examination (E-17073117-050.06)

Exclusion criteria:

Patients under 50 years of age, Patients with negative COVID 19 pcr test, Lymphatic system disease or malignant hematological diseases were excluded from the study.

Patient age, gender, education status,time spent at home before hospitalization ,duration of hospitalization, alcohol/tobacco use, body mass index,presence of thorax CT lesion ,whether the patients were discharged to another service, intensive care unit, or home after the treatment of COVID 19,laboratory findings at admission and discharge (lymphocyte level, neutrophil-lymphocyte ratio and platelet count at first admission) were recorded.

To evaluate the lifestyle before being infected with COVID 19, physical activity, nutrition and sleep habits were questioned.

To evaluate sleep habits; Pittsburg Sleep Quality Scale (PSQS) , Nutritional habits; Mini Nutritional Assessment(MNA) Scale, For the evaluation of physical activity; International Brief Physical Activity Questionnaire Done. ;

Related Conditions & MeSH terms

• COVID-19
• Lifestyle Factors

• NCT number: NCT05197478
• Study type: Interventional
• Source: Fatih Sultan Mehmet Training and Research Hospital
• Status: Active, not recruiting
• Phase: N/A
• Start date: January 1, 2021
• Completion date: February 1, 2022