Prevention and Treatment of Patient Before, During, and After Covid-19 Infection

Covid19 Clinical Trial

— AntiCov-220  

Official title:

Prevention and Treatment of Patient Before, During, and After Covid-19 Infection

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05043324
• Other study ID #: COVID-19 and Immunodeficiency
• Status: Completed
• Phase: Phase 2
• Start date: February 20, 2020
• Est. completion date: April 27, 2022

Study information

• Verified date: April 2022
• Source: Trieu, Nguyen Thi, M.D.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

AntiCov-220 prevents and treats before, during, and after infection with SARS-Cov-2. The composition is fractionally extracted from herbs, using flavonoids, isoflavonoids, and pregnenolone in combination with ascorbic acid as the key compounds in preventing and killing SARS-CoV-2; increase antibodies and protect cells; supplementing precursors to help the body strengthen antibodies and reduce the risk of infection; destroy spike protein, toxic protein, help prevent blood clots causing stroke; restore the physiological function of cells after virus infection; helps the body to stabilize the amount of cortisol in the blood as well as stabilize the production of specific antibodies. The composition participates in anti-inflammatory and cells protecting process, bringing blood cortisol, B-lymphocytes, Cyfra 21-1, WBC, CRP, fever, dyspnea, and other signs of respiratory tract inflammation to a normal state and normal limit.

Description:

AntiCov-220 can eliminate COVID-19 and its variants at a very early stage when they have not had enough time to multiply and cause disease. AntiCov-220 contains precursors, flavonoids, special enzymes responsible for protecting human cell membranes and destroying cell membranes of some viruses, especially, COVID-19 cannot replicate in the presence of AntiCov-220 in the body.

AntiCov-220 contains precursors of cortisol. As the investigators know, cortisol has a cell anti-inflammatory, blood pressure regulation, blood sugar regulation, energy booster, and anti-stress role. It provides precursors to help direct and balance the amount of cortisol in the body that has been imbalanced before.

AntiCov-220 contains flavonoids and Isoflavonoids that are cytoprotective antioxidants, clinically proven to destroy SARS-CoV-2, HBV, HIV, HCV, viruses, reduce complications after COVID-19 infection, prevent neurological sequelae, stroke, cardiovascular sequelae, respiratory sequelae, ...

The anti-inflammatory, stress-reducing, cell-protective, anti-viral, and immunosuppressive process are performed by an in vivo method that has proven its effectiveness more than ten years ago. AntiCov-220 is an innovative product that can fight against COVID-19 and its variants in the current epidemic situation.

AntiCov-220 is committed to protecting the community of people infected with HBV, HIV, HCV, SARS-CoV-2 against the risk of the COVID-19 pandemic and its mutations.

AntiCov-220 easy to implement, highly effective, and helps reduce public health costs, which is essential in protecting human health.

AntiCov-220 can be used alongside with current standard treatment regimens prescribed by the World Health Organization.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 82
• Est. completion date: April 27, 2022
• Est. primary completion date: April 20, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 16 Years to 82 Years

Eligibility

Inclusion Criteria:

• All patients with underlying medical conditions who have been taking medications for these conditions.

• Patients with AIDS, HIV, HBV, HCV, and patients with co-infections.

• The cancer patients are stable.

• Patients with congenital or acquired immunodeficiency.

Exclusion Criteria:

• Unstable cancer patients.

Related Conditions & MeSH terms

• COVID-19
• Covid19

Intervention

Drug:
• AntiCov-220 (1)
The daily maintenance, AntiCov-220 (1) dose is to take 3 times a day, 1 tablet each time.
• AntiCov-220 (2)
The daily maintenance, AntiCov-220 (2) dose is to take 3 times a day, 1 tablet each time.

Locations

Country	Name	City	State
Vietnam	Saigon Biopharma Company Limited	Ho Chi Minh City

Sponsors (1)

Lead Sponsor	Collaborator
Nguyen Thi Trieu, MD

Country where clinical trial is conducted

Vietnam, 

References & Publications (15)

Ayatollahi A, Bagheri S, Ashraf-Ganjouei A, Moradi K, Mohammadi MR, Akhondzadeh S. Does Pregnenolone Adjunct to Risperidone Ameliorate Irritable Behavior in Adolescents With Autism Spectrum Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical — View Citation

Barzilay JI, Blaum C, Moore T, Xue QL, Hirsch CH, Walston JD, Fried LP. Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. Arch Intern Med. 2007 Apr 9;167(7):635-41. — View Citation

Clinical characteristics, multi-organ dysfunction, and outcomes of patients with COVID-19: A prospective observational study

Herbal Support for Adrenal Function BY JAMES ROUSE, N.D.

Jones QR, Warford J, Rupasinghe HP, Robertson GS. Target-based selection of flavonoids for neurodegenerative disorders. Trends Pharmacol Sci. 2012 Nov;33(11):602-10. doi: 10.1016/j.tips.2012.08.002. Epub 2012 Sep 12. Review. — View Citation

Krest I, Keusgen M. Stabilization and pharmaceutical use of alliinase. Pharmazie. 1999 Apr;54(4):289-93. — View Citation

Lessel D, Kubisch C. Hereditary Syndromes with Signs of Premature Aging. Dtsch Arztebl Int. 2019 Jul 22;116(29-30):489-496. doi: 10.3238/arztebl.2019.0489. Review. — View Citation

Majewski M. Allium sativum: facts and myths regarding human health. Rocz Panstw Zakl Hig. 2014;65(1):1-8. Review. — View Citation

Naran K, Nundalall T, Chetty S, Barth S. Principles of Immunotherapy: Implications for Treatment Strategies in Cancer and Infectious Diseases. Front Microbiol. 2018 Dec 21;9:3158. doi: 10.3389/fmicb.2018.03158. eCollection 2018. Review. — View Citation

Natural Products Structural Diversity-I Secondary Metabolites: Organization and Biosynthesis

Roth A, Schaffner W, Hertel C. Phytoestrogen kaempferol (3,4',5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity. J Neurosci Res. 1999 Aug 1;57(3):399-404. — View Citation

Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, Emwas AH, Jaremko M. Important Flavonoids and Their Role as a Therapeutic Agent. Molecules. 2020 Nov 11;25(22). pii: E5243. doi: 10.3390/molecules25225243. Review. — View Citation

van Gorkom GNY, Klein Wolterink RGJ, Van Elssen CHMJ, Wieten L, Germeraad WTV, Bos GMJ. Influence of Vitamin C on Lymphocytes: An Overview. Antioxidants (Basel). 2018 Mar 10;7(3). pii: E41. doi: 10.3390/antiox7030041. Review. — View Citation

van Gorkom GNY, Lookermans EL, Van Elssen CHMJ, Bos GMJ. The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review. Nutrients. 2019 Apr 28;11(5). pii: E977. doi: 10.3390/nu11050977. — View Citation

Vitamin C (Ascorbic Acid) Muhammad Abdullah; Radia T. Jamil; Fibi N. Attia.

* Note: There are 15 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessment on the level of safety and tolerability of patients against the effects of Covid-19.(Arm 1)	COVID-19 is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Anticov-220 characterized by the targeting and destruction of COVID-19; One case of Covid-19 infection with no severe change in a patient with HBeAg (+).; A case of HIV/AIDS turns back to HIV. Of the 35 follow-up subjects in this group, 20 were vaccinated and 15 were not. (The two cases mentioned above have not been vaccinated).	- 18 months
Secondary	Assessment on the level of safety and tolerability of patients against the effects of Covid-19.(Arm 2)	COVID-19 is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Anticov-220 characterized by the targeting and destruction of COVID-19; _ No one has been infected with Covid-19. Of the 47 follow-up subjects in this group, 40 were vaccinated and 7 were unvaccinated.	- 18 months

External Links

•   Ageing and health
•   Antiretrovirals: HIV and AIDS Drugs
•   Be aware of SARS-CoV-2 spike protein: There is more than meets the eye
•   Medically Reviewed by Arefa Cassoobhoy, MD, MPH
•   Top Foods High in Flavonoids