The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection

Covid19 Clinical Trial

Official title:

The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection: A Retrospective Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04945577
• Other study ID #: Gulcanozturk
• Status: Completed
• Start date: July 1, 2020
• Est. completion date: August 1, 2020

Study information

• Verified date: June 2021
• Source: Fatih Sultan Mehmet Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis COVID19.The aim of this study was to determine the relationship between 25OH vitamin D levels, inflammatory laboratory parameters of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) levels and disease severity of COVID19 infection.

Description:

In this retrospective study 300 patients diagnosed with COVID19 were included. According to clinical classification of cases with COVID19 the patients were divided into three groups; mild (Group1), moderate (Group2) and severe/critical (Group3). The 25OH vitamin D values below 20 ng/ml were defined as deficiency, 21-29 ng/ml were defined as insufficiency, and 30 ng/ml and above were defined as normal. Patients' age, gender, comorbid diseases and laboratory values were recorded

Recruitment information / eligibility

• Status: Completed
• Enrollment: 300
• Est. completion date: August 1, 2020
• Est. primary completion date: August 1, 2020
• Gender: All
• Age group: 16 Years to 97 Years

Eligibility

Inclusion Criteria:

• The study included 300 polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months

Exclusion Criteria:

• Patients with COVID-19 whose 25-OH vitamin D levels were not measured in the last 6 months before the COVID-19 diagnosis were excluded from the study

Related Conditions & MeSH terms

• Covid19
• Vitamin D Deficiency

Intervention

Diagnostic Test:
• Inflammatory Parameters
Laboratory measurement of patient's inflammatory status in unit of % and mg/dl

Other:
• 25 OH Vitamin D Level
Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl

Locations

Country	Name	City	State
Turkey	Gulcan Ozturk	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Fatih Sultan Mehmet Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

References & Publications (3)

Ali N. Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19. J Med Virol. 2020 Nov;92(11):2409-2411. doi: 10.1002/jmv.26097. Epub 2020 Jun 9. — View Citation

Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. J Infect Public Health. 2020 Oct;13(10):1373-1380. doi: 10.1016/j.jiph.2020.06.021. Epub 2020 Jun 20. Review. — View Citation

Khemka A, Suri A, Singh NK, Bansal SK. Role of Vitamin D Supplementation in Prevention and Treatment of COVID-19. Indian J Clin Biochem. 2020 Jul 30:1-2. doi: 10.1007/s12291-020-00908-3. [Epub ahead of print] — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	25-OH vitamin D	laboratory measurement in unit of ng/ml	1 day
Primary	White blood cell count	laboratory measurement in unit of x103/uL	1 day
Primary	neutrophil count	laboratory measurement in unit of x103/uL	1 day
Primary	neutrophil ratio	laboratory measurement in unit of %	1 day
Primary	lymphocyte count	x103/uL	1 day
Primary	lymphocyte ratio	laboratory measurement in unit of %	1 day
Primary	platelet count	laboratory measurement in unit of x103/uL	1 day
Primary	hemoglobin count	laboratory measurement in unit of g/dl	1 day
Primary	C-reactive protein levels	laboratory measurement in unit of mg/dL	1 day
Primary	neutrophil to lymphocyte ratio	laboratory measurement in unit of %	1 day
Primary	platelet to lymphocyte ratio	laboratory measurement in unit of %	1 day