Safety, Tolerability and Immunogenicity of the Candidate Vaccine MVA-SARS-2-ST Against COVID-19

Covid19 Clinical Trial

— MVA-SARS2-ST  

Official title:

A Multi-center Phase Ib Trial to Assess the Safety, Tolerability and Immunogenicity of the Candidate Vaccine MVA-SARS-2-ST in Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04895449
• Other study ID #: UKE-SARS-CoV-2-ST
• Status: Completed
• Phase: Phase 1
• Start date: July 16, 2021
• Est. completion date: November 8, 2022

Study information

• Verified date: January 2023
• Source: Universitätsklinikum Hamburg-Eppendorf
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Multi-center phase Ib study to evaluate the Modified Vaccinia Virus Ankara (MVA) vaccine against SARS-CoV-2 in seronegative (Part A) and previously SARS-CoV-2-vaccinated individuals (Part B).

Description:

The vaccine contains a Modified Vaccinia Virus Ankara (MVA) vector expressing a stabilized SARS-CoV-2 spike protein (S). This will be a phase Ib multi-center study in approximately 60 adults aged 18-64 years. Part A (N=24 seronegative subjects). Each participant will receive two single injections, 28 days apart. - low dose ≥ 1 x 10e7 IU (N=8) - middle dose ≥ 5 x 10e7 IU (N=8) - high dose ≥ 1 x 10e8 IU (N=8) Part B (N=36 previously mRNA vaccinated subjects). Each participant will receive a single injection. - low dose ≥ 1 x 10e7 IU (N=12) - middle dose ≥ 5 x 10e7 IU (N=12) - high dose ≥ 1 x 10e8 IU (N=12) All participants will be followed up for safety until D168.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 43
• Est. completion date: November 8, 2022
• Est. primary completion date: November 2, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 64 Years

Eligibility

Inclusion Criteria:

1. Written informed consent.

2. Healthy male and female adults aged 18 - 64 at time of informed consent.

3. Body mass index 18.5 - 32.0 kg/m2 and weight > 50 kg at screening.

4. Female participants: non-pregnant, non-lactating with negative pregnancy test.

5. Females who agree to comply with the applicable contraceptive requirements of the protocol.

6. = 6 months fully vaccinated with a (conditionally)licensed mRNA vaccine against COVID-19 (Part B only)

Exclusion Criteria:

1. Receipt of any vaccine from 4 weeks prior to each trial vaccination (8 weeks for live vaccines) to 6 weeks after each trial vaccination.

2. Previous rMVA immunization.

3. Previous immunization with investigational vaccine against COVID-19.

4. Previous immunization with EUA/conditionally licensed vaccine against COVID-19 (not applicable to Part B).

5. Evidence of active SARS-CoV-2 infection

6. Known allergy to the components of the MVA-SARS-2-ST vaccine product or history of life-threatening reactions to vaccine containing the same substances.

7. Known history of anaphylaxis to vaccination or any allergy likely to be exacerbated by any component of the trial vaccines.

8. Evidence in the participant's medical history or in the medical examination that might influence either the safety of the participant or the absorption, distribution, metabolism or excretion of the investigational product.

9. Clinically relevant findings in ECG or significant thromboembolic events in medical history.

10. Any confirmed or suspected immunosuppressive or immunodeficient condition, cytotoxic therapy in the previous 5 years, and/or uncontrolled diabetes (HbA1c = 7.0).

11. Any known chronic or active neurologic disorder, including seizures and epilepsy, excluding a single febrile seizure as a child.

Related Conditions & MeSH terms

• COVID-19
• Covid19

Intervention

Biological:
• MVA-SARS-2-ST
i.m. vaccine administration

Locations

Country	Name	City	State
Germany	Uniklinik Köln	Cologne	NRW
Germany	CTC North	Hamburg

Sponsors (6)

Lead Sponsor	Collaborator
Universitätsklinikum Hamburg-Eppendorf	Clinical Trial Center North (CTC North GmbH & Co. KG), German Center for Infection Research, IDT Biologika, Ludwig-Maximilians - University of Munich, Philipps University Marburg Medical Center

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of Participants Experiencing Solicited Local or Systemic Reactogenicity as Defined by the Study Protocol	Safety and reactogenicity will be assessed by observation, questionaire and diary. Occurence of Serious Adverse Events (SAE) will be collected throughout the entire study duration.	during the entire study (up to 6 months)
Secondary	Number of participants who seroconverted	Magnitude of SARS-CoV-2-S specific antibody responses will be measured by ELISA and neutralization assays	during the entire study (up to 6 months)