Clinical Trial Details
— Status: Not yet recruiting
Administrative data
NCT number |
NCT04839068 |
Other study ID # |
covid2021 |
Secondary ID |
|
Status |
Not yet recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
May 1, 2021 |
Est. completion date |
June 2022 |
Study information
Verified date |
April 2021 |
Source |
Assiut University |
Contact |
Reham Ahmed Abdel Rahim, Resident |
Phone |
01029923849 |
Email |
elkadyreeham[@]gmail.com |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
This study is aiming to evaluate the effects of the COVID-19 pandemic stress on pregnancy
outcomes including the sex ratio at birth.
Description:
- Coronavirus disease 2019 (COVID-19) is an emerging respiratory disease caused by a
single-strand, positive-sense ribonucleic acid (RNA) virus, severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) virus (Masters, 2019).
- The sex ratio (ratio of boys to girls) at birth (SRB) is about 1.01-1.05 in most
populations (Abdoli, 2020). Various influencing factors affect the SRB, including
maternal stress, endocrine disruption, maternal inflammatory responses and maternal
nutrition (Lipner et al., 2019).
- These stressful life events consequently influence on maternal immunological and
endocrine conditions, and the male fetuses are more vulnerable to be affected by these
conditions. It is of interest that male fetus is biologically weaker and more
susceptible to prenatal events and diseases than female fetuses. Hence, premature death
is higher in boys than girls (Ahrenfeldt et al., 2017).
- The recent pandemic of the coronavirus disease 2019 (COVID-19) has been known to have
various impacts on pregnant women (Rasmussen et al., 2020). Placentas of infected
mothers show inflammatory, vascular and thrombotic changes (Prochaska et al., 2020).
Among the neonates, children and adults (Bjelosevic et al., 2017), higher morbidity and
mortality of males than females were reported. It is observed that the incidence of
stillbirth was significantly increased during the pandemic period than during the pre
pandemic period in London, UK (Khalilet al., 2020).
- The start of appearance of Covid 19 cases in Egypt was in March 2020, with subsequent
increase in cases with its peak in May, June and July 2020, with lockdown and social and
financial affection with great stress on families