COVID-19 Clinical Trial
Official title:
Longitudinal and Comparative Study of Morphological Abnormalities of the Olfactory Bulb on MRI and Olfactometry in Anosmic Versus Normosmic COVID-19 Patients
Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients. This study aimed to detect these disturbances among positive COVID-19 patients (symptom not initially highlighted by the patient and not sought by caregivers) in order to allow early management of olfactory and gustatory dysfunction.
Several medical teams have recently shown that disturbances of smell and taste are common and
can be a precursor and even an isolated sign of COVID-19 involvement. Preliminary results
suggest the presence of clinical MRI abnormalities, particularly in the olfactory bulbs in
anosmic patients with COVID-19.
Anosmia and taste disturbance are early warning signs that could be important in improving
the detection and diagnosis of COVID-19, and also in monitoring disease. In addition,
disturbances in smell and taste could be an aid in establishing the prognosis of the clinical
course of the viral disease. The question of olfactory recovery is also fundamental. To date,
we do not know the possibilities of recovery from COVID-19 post viral anosmia. ENT exams,
olfactometry and MRI are proposed to study these phenomena.
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NCT number | NCT04526054 |
Study type | Interventional |
Source | Hopital Foch |
Contact | Elisabeth Hulier-Ammar, Dr |
Phone | 0033146251175 |
[email protected] | |
Status | Recruiting |
Phase | N/A |
Start date | September 3, 2020 |
Completion date | September 3, 2021 |
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