Covid19 Clinical Trial
— COVAPOfficial title:
Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia: COVAP Study
Verified date | March 2023 |
Source | Groupe Hospitalier Paris Saint Joseph |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
A Respiratory infection with the SARS-CoV2 virus is associated with a major risk of viral pneumonia that can lead to respiratory distress requiring resuscitation. In the most severe forms, it may require mechanical ventilation or even lead to an acute respiratory distress syndrome with a particularly poor prognosis. The SARS-CoV2 is a single-stranded RNA virus of positive polarity and belongs to the beta genus of Coronaviruses. SARS-CoV2 is responsible for the third epidemic in less than twenty years secondary to a Coronavirus (SARS-CoV then MERS-CoV) and if the mortality associated with it is lower than that of previous strains, notably MERS-CoV, its spread is considerably big. As a result, the number of patients developing respiratory distress requiring invasive mechanical ventilation is high, with prolonged ventilation duration in these situations
Status | Active, not recruiting |
Enrollment | 22 |
Est. completion date | April 30, 2023 |
Est. primary completion date | September 10, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patient whose age = 18 years old - French-speaking patient - Patient whose COVID-19 infection was diagnosed by either a laboratory test, PCR or any other commercial or public health test. - Adult acute respiratory distress syndrome according to the Berlin definition - Pneumonia acquired under mechanical ventilation defined according to the criteria of international companies Exclusion Criteria: - Patient/family or proxy opposing participation in the study - Patient under guardianship or curatorship - Patient deprived of liberty - Patient under the safeguard of justice. |
Country | Name | City | State |
---|---|---|---|
France | Groupe Hospitalier Paris Saint-Joseph | Paris |
Lead Sponsor | Collaborator |
---|---|
Groupe Hospitalier Paris Saint Joseph | Centre Hospitalier Victor Dupouy |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Research of the bacteria responsible for nosocomial pneumonia | Establishing a biobank of the bacterial agents responsible for nosocomial pneumonia acquired under mechanical ventilation in order to: better understand the particularities of the bacteria responsible and obtain the "clinical" strains for in vitro studies that will be carried out secondarily. | 6 months | |
Secondary | Additional evaluations to the study | Evaluation of the adhesion properties to the bronchial epithelium (LPS peculiarities of Gram-negative bacteria, the interaction with the virus in in vitro models and the different molecules of interest in the collected bronchial secretions). | 6 months |
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