COVID-19 Clinical Trial
Official title:
Consequences of the COVID-19 Pandemic on Worldwide Organ Procurement and Transplantation
End-stage organ failure is estimated to affect more than 4 to 6 million persons worldwide. In
2018, transplant systems across the globe enabled around 150,000 patients to benefit from a
kidney, heart, lung, liver, or other solid organ, a number that was far less than the demand.
According to data from the World Health Organization, more than 1,500,000 persons live with a
transplanted organ worldwide. In the US, approximately 40,000 patients receive an organ
transplant every year, but 120,000 still remain waitlisted for transplantation today, with
7,600 dying annually while waiting for an organ transplant. A similar lack of organs and high
death rates on the waiting list affect patients in Europe and many other countries.
As nations adjust to new realities driven by the coronavirus (COVID-19) outbreak, many health
care providers, institutions and patients are concerned about the potential impact that
COVID-19 will have on organ donation and transplantation. One concern is that transplant
recipients may have a greater susceptibility to infection and greater viral burden. A second
concern is that hospitals will lack the resources in terms of staff and equipment to care for
recipients after transplantation, who often require intensive care and multispecialty
management.
Because of the overwhelming healthcare system burden, a dramatic negative effect on worldwide
organ donation and transplantation is anticipated, but has not been measured. Our objective
was to quantify the worldwide impact of COVID-19 pandemic on organ donation and
transplantation and consequences for waitlisted patients.
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