COVID-19 Clinical Trial
Official title:
Prospective Randomized Open-label Trial of Atorvastatin as Adjunctive Treatment of COVID-19
Objective: To assess whether adjunctive therapy of COVID-19 infection with atorvastatin reduces the deterioration in hospitalized patients and improves clinical outcome.
COVID-19 is caused by SARS-CoV-2, a β-coronavirus that binds to the zinc peptidase angiotensin-converting enzyme 2 (ACE2). No drug is licensed to treat COVID-19, but adjunctive pharmacologic interventions have been proposed for their immunomodulatory effects, including statins. About 5% of cases are considered critical, with severe respiratory failure as well as myocarditis, and thromboses, and are associated with high fatality rate. Statins affect endothelial dysfunction and have anti-inflammatory and immunomodulatory effects. This prospective, randomized, open-label trial of atorvastatin as adjunctive treatment of COVID-19 in hospitalized patients aims to study: 1. Will atorvastatin reduce progression to severe or critical COVID-19 disease and death compared to standard care? 2. Will atorvastatin lead to improved clinical outcome of COVID-19 disease at 30 days compared to standard care? ;
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