Covid19 Clinical Trial
— AMBU-COVIDOfficial title:
Proactive Care of Ambulatory COVID19 Patients: Open-labeled Randomized Trial
Verified date | March 2023 |
Source | Centre Hospitalier Universitaire, Amiens |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
On January 9, 2020, a new emerging virus was identified by WHO as being responsible for grouped cases of pneumonia in China. It is a coronavirus, SARS-CoV-2, responsible for the disease COVID-19 (Coronavirus disease). The disease is mild in 85% of cases but the proportion of serious cases requiring hospitalization or intensive care (15%) puts stress on health structures and systems around the world. To limit the influx of patients and avoid overstretching Health systems, containment and social distancing strategies are widely adopted. It appears crucial to propose the easiest possible therapeutic strategy taking into account the ambulatory nature of the patients. Therefore azithromycin (AZM) is an antibiotic known to have an antiviral effect but also which has anti-inflammatory activity in addition to its antimicrobial effect. Azithromycin targets preferentially pulmonary cells (and particularly of the lines apparently affected in COVID-19 positive cases). The aim of this study is to demonstrate that AZM decreases symptom duration in COVID19 patients and diminishes the viral carriage.
Status | Suspended |
Enrollment | 11 |
Est. completion date | July 1, 2023 |
Est. primary completion date | June 1, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients treated at the CHU Amiens Picardie presenting: - Age =18 years - Showing symptoms of COVID -19 and a positive RT-PCR by nasopharyngeal swab - Non-severe patient, outpatient (not hospitalized), without oxygen - Having signed a consent to participate in the study Exclusion Criteria: - Patient with a contraindication to taking azithromycin, namely: Allergy to macrolides, Severe liver failure. - In combination with medicines containing cisapride, colchicine, ergotamine or dihydroergotamine - Pregnant, parturient or breastfeeding women. - Asymptomatic patients - Patient unable to be compliant with study protocol - Patient under guardianship or curators, under the protection of justice or private public law. |
Country | Name | City | State |
---|---|---|---|
France | CHU Amiens | Amiens |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire, Amiens |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Length of symptom duration (in days) with azithromycin treatment | Length of symptom duration (in days) with azithromycin treatment | up to 2 months |
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