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VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL) — VA-REACH  

COVID-19 Clinical Trial

Official title:
VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL)

Clinical Trial Summary

We propose a 3-arm RCT to determine the efficacy of hydroxychloroquine or azithromycin in treating mild to moderate COVID-19 among Veterans in the outpatient setting.

Clinical Trial Description

SARS-CoV-2 is a novel coronavirus disease (COVID-19) that presents with fever, cough, and shortness of breath, and has a mortality rate of 2-4%. Outcomes are worse among the elderly and those with cardiovascular, respiratory, cancer and other co-morbidities. Several treatments are also emerging as promising therapeutic candidates, hydroxychloroquine and azithromycin - both available as generic pills and widely used for other indications - are potential options for treatment. A small randomized controlled trial (RCT) of hospitalized patients suggests chloroquine may be superior to placebo in promoting viral elimination and shortening disease course. Hydroxychloroquine is preferred to chloroquine in the U.S. A small non-randomized trial found azithromycin had a clinical benefit. When azithromycin and hydroxychloroquine are given together, they can cause cardiac side-effects that limit use in the outpatient setting. These drugs, however, have independent potential benefits against COVID-19 that require more rigorous study before either is considered standard of care. We propose a 3-arm RCT to determine the efficacy of hydroxychloroquine or azithromycin in treating mild to moderate COVID-19 among Veterans in the outpatient setting. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04363203
Study type Interventional
Source San Francisco VA Health Care System
Contact
Status Suspended
Phase Phase 3
Start date April 30, 2020
Completion date August 2021
View Details
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