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NCT04333550 Clinical Trial

Application of Desferal to Treat COVID-19

COVID-19 Clinical Trial

Official title:
Application of Iron Chelator (Desferal) to Reduce the Severity of COVID-19 Manifestations

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04333550
Other study ID # 1398.1224
Secondary ID
Status Recruiting
Phase Phase 1/Phase 2
First received
Last updated
Start date April 2020
Est. completion date March 2021

Study information
Verified date April 2020
Source Kermanshah University of Medical Sciences
Contact Alireza Ghaffarieh, MD
Phone +1-608-698-7334
Email alirezaghaffariyeh@hotmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In this study, defined cases of COVID-19 with mild, moderate or severe pneumonia will be treated with standard treatment regimens in combination with IV injection of Deferoxamine. Improvement in clinical, laboratory and radiological manifestations will be evaluated in treated patient compared to control group.

Recruitment information / eligibility
Status Recruiting
Enrollment 50
Est. completion date March 2021
Est. primary completion date September 2020
Accepts healthy volunteers No
Gender All
Age group 3 Years to 99 Years
Eligibility Inclusion Criteria:

Clinical diagnosis of COVID-19 Disease,

Exclusion Criteria:

Previous history of allergy to Deferoxamin, Pregnancy, kidney dysfunction,

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Deferoxamine
Intravenous infusion of Deferoxamine

Locations
Country Name City State
Iran, Islamic Republic of Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Kermanshah

Sponsors (1)
Lead Sponsor Collaborator
Kermanshah University of Medical Sciences

Country where clinical trial is conducted

Iran, Islamic Republic of, 

References & Publications (17)

Chang HC, Bayeva M, Taiwo B, Palella FJ Jr, Hope TJ, Ardehali H. Short communication: high cellular iron levels are associated with increased HIV infection and replication. AIDS Res Hum Retroviruses. 2015 Mar;31(3):305-12. doi: 10.1089/aid.2014.0169. Epub — View Citation

Cinatl J Jr, Cinatl J, Rabenau H, Gümbel HO, Kornhuber B, Doerr HW. In vitro inhibition of human cytomegalovirus replication by desferrioxamine. Antiviral Res. 1994 Sep;25(1):73-7. — View Citation

Cinatl J, Scholz M, Weber B, Cinatl J, Rabenau H, Markus BH, Encke A, Doerr HW. Effects of desferrioxamine on human cytomegalovirus replication and expression of HLA antigens and adhesion molecules in human vascular endothelial cells. Transpl Immunol. 199 — View Citation

Drakesmith H, Prentice A. Viral infection and iron metabolism. Nat Rev Microbiol. 2008 Jul;6(7):541-52. doi: 10.1038/nrmicro1930. Review. — View Citation

Duchemin JB, Paradkar PN. Iron availability affects West Nile virus infection in its mosquito vector. Virol J. 2017 Jun 5;14(1):103. doi: 10.1186/s12985-017-0770-0. — View Citation

Georgiou NA, van der Bruggen T, Oudshoorn M, Nottet HS, Marx JJ, van Asbeck BS. Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxamine, deferiprone, and bleomycin. J Infect Dis. 20 — View Citation

Giannakopoulou E, Pardali V, Zoidis G. Metal-chelating agents against viruses and parasites. Future Med Chem. 2018 Jun 1;10(11):1283-1285. doi: 10.4155/fmc-2018-0100. Epub 2018 May 3. Review. — View Citation

Gordeuk V, Thuma P, Brittenham G, McLaren C, Parry D, Backenstose A, Biemba G, Msiska R, Holmes L, McKinley E, et al. Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. N Engl J Med. 1992 Nov 19;327(21):1473-7. — View Citation

Mabeza GF, Loyevsky M, Gordeuk VR, Weiss G. Iron chelation therapy for malaria: a review. Pharmacol Ther. 1999 Jan;81(1):53-75. Review. — View Citation

Meyer D. Iron chelation as therapy for HIV and Mycobacterium tuberculosis co-infection under conditions of iron overload. Curr Pharm Des. 2006;12(16):1943-7. Review. — View Citation

Nairz M, Haschka D, Demetz E, Weiss G. Iron at the interface of immunity and infection. Front Pharmacol. 2014 Jul 16;5:152. doi: 10.3389/fphar.2014.00152. eCollection 2014. Review. — View Citation

Paradkar PN, De Domenico I, Durchfort N, Zohn I, Kaplan J, Ward DM. Iron depletion limits intracellular bacterial growth in macrophages. Blood. 2008 Aug 1;112(3):866-74. doi: 10.1182/blood-2007-12-126854. Epub 2008 Mar 27. — View Citation

Sappey C, Boelaert JR, Legrand-Poels S, Forceille C, Favier A, Piette J. Iron chelation decreases NF-kappa B and HIV type 1 activation due to oxidative stress. AIDS Res Hum Retroviruses. 1995 Sep;11(9):1049-61. — View Citation

Visseren F, Verkerk MS, van der Bruggen T, Marx JJ, van Asbeck BS, Diepersloot RJ. Iron chelation and hydroxyl radical scavenging reduce the inflammatory response of endothelial cells after infection with Chlamydia pneumoniae or influenza A. Eur J Clin In — View Citation

Vlahakos D, Arkadopoulos N, Kostopanagiotou G, Siasiakou S, Kaklamanis L, Degiannis D, Demonakou M, Smyrniotis V. Deferoxamine attenuates lipid peroxidation, blocks interleukin-6 production, ameliorates sepsis inflammatory response syndrome, and confers r — View Citation

Wang H, Li Z, Niu J, Xu Y, Ma L, Lu A, Wang X, Qian Z, Huang Z, Jin X, Leng Q, Wang J, Zhong J, Sun B, Meng G. Antiviral effects of ferric ammonium citrate. Cell Discov. 2018 Mar 27;4:14. doi: 10.1038/s41421-018-0013-6. eCollection 2018. — View Citation

Weinberg GA. Iron chelators as therapeutic agents against Pneumocystis carinii. Antimicrob Agents Chemother. 1994 May;38(5):997-1003. — View Citation

* Note: There are 17 references in all — Click here to view all references

Outcome
Type Measure Description Time frame Safety issue
Primary Mortality rate All cause of death up to 20 days
Secondary change in patients clinical manifestation Mild, Moderate or Severe up to 20 days
Secondary change in patients PaO2 up to 20 days
Secondary Length of hospitalization days up to 20 days
Secondary C-reactive protein up to 20 days
Secondary lymphocyte count up to 20 days
Secondary length of intensive care unit stay 1 to 20 days
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