COVID-19 Disease, Severe Form Clinical Trial
Official title:
A Multicentric Survey on Patients Over 60 Admitted to Intensive Care for Severe Forms of COVID Infection: Search for Prognostic Criteria Associated With Survival
With the spread of COVID-19 epidemic since 2019 in Wuhan, China health plans have to be
adapted continuously in response to the emergency. The first publications from the Chinese
experience demonstrate an increase in the incidence of COVID-19 infections in patients over
60 years of age, a higher frequency of severe forms of the disease and therefore theoretical
indications of orientation towards resuscitative care.
However, the first published data from Hubei province suggest a low benefit of resuscitation
for patients between 70 and 80 years of age and null in patients over 80 years of age. These
data question the individual benefit / risk balance of an orientation towards resuscitation
for this category of patients, their quality of life and the concept of unreasonable
obstinacy.
Among the covariates associated with resuscitation mortality described in the data published
to date, cardiovascular comorbidities, certain biological covariates (LDH, creatinine,
lymphocytes, neutrophils, TP, D-dimers, etc.), the time between the first symptoms and the
entry into resuscitation have been identified.
The objective of this multicentric observational study is to determine the clinical and
biological covariates predictive of mortality in the population of patients over 60 years of
age admitted in intensive care unit, in particular by integrating functional and nutritional
data from patients 1 month before COVID-19 infection.
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