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NCT ID: NCT05300412 Completed - Clinical trials for Breast Cancer Invasive

The Role of Interleukin-7 Serum Level as Biological Marker in Breast Cancer

Start date: June 5, 2018
Phase:
Study type: Observational

The aim of this study has been to explore whether there is any elevation of Interleukin-7 serum level in the early invasive breast cancer (EIBC) patients in comparison with healthy controls. In addition the correlation between the Interleukin-7 serum level and histopathological characteristics of the tumor, has been evaluated. We have hypothesized that Interleukin-7 serum level is elevated in the patients diagnosed with early invasive BC in comparison with healthy control group, and positively correlates with the tumor size, poor cell differentiation, lymphovascular and perineural invasion, negative hormone receptors' status, axillary lymph node metastasis, and the high Ki-67 proliferation index. In addition, no difference in the Interleukin-7 serum level exists between the patients recruited in Croatia and Kosovo, respectively. This cross-sectional, observational, and analytical study has included 213 consecutive patients with EIBC (113 from Croatia and 100 from Kosovo) and 62 healthy participants as the control group (30 from Croatia and 32 from Kosovo). Blood samples have been taken from patients confirmed with breast cancer (BC) by biopsy, prior to surgical intervention and other oncological treatments, as well as from healthy participants. Interleukin-7 serum level has been measured, using "Sandwich" ELISA Immunoenzyme test. In addition, after the surgical intervention, the histopathological specimen examinations and the immunohistochemistry have been performed and analyzed. The differences of the distribution of the numerical variables have been analyzed with Mann-Whitney U test and Kruskal-Wallis ANOVA test. Correlations have been tested with Pearson coefficients. P value <0.05 has been accepted as statistically significant.

NCT ID: NCT05156151 Enrolling by invitation - Stromal Keratitis Clinical Trials

Stromal Lenticule Implantation for Management of Herpetic Stromal Keratitis

Relex-Smile
Start date: January 1, 2017
Phase: N/A
Study type: Interventional

The aim of this study is the evaluation of corneal transparency and improvement of visual acuity in patients with herpetic stromal keratitis.

NCT ID: NCT05137015 Recruiting - Injury Prevention Clinical Trials

Preventing Injuries in Young Football Players

Start date: September 4, 2021
Phase: N/A
Study type: Interventional

Football is the most popular sport in the world, with 260 million male and female active participants, including ~113,000 FIFA registered professional players. Playing football is fun and can provide many health benefits, however, it also presents a high injury risk. Studies on elite and non-elite footballers have reported similar injury rates in both genders. The most common football-related injuries are the knee and ankle ligament and thigh muscle strains, Over the past two decades, significant advancement has been made in the field of injury prevention in football. There are used trials to prevent specific injuries, as ankle sprain, ACL injuries, hamstring strains, etc. On the other hand, there are created programs designed to prevent a wider spectrum of injuries like FIFA11+. Therefore, the aim of this study is to investigate the effect of a new injury prevention program on the overall injury incidence in young football players.

NCT ID: NCT05123014 Active, not recruiting - Clinical trials for Adenoviral Keratoconjunctivitis

Lenticule Implantation and Autologous Serum New Approach in Treatment of Adenoviral Keratitis Disease

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

Adenoviral keratitis(caused by adenovirus) is one of the most frequently diagnosed eye diseases. Most of these infections have symptoms like (Ocular itchiness and irritation, chemosis (conjunctival edema),photophobia, epiphora, foreign body sensation, epithelial keratitis etc.Adenoviral subepithelial infiltration is one of the most difficult complication to treat. Our purpose is to evaluate corneal transparency, recurrence, and visual acuity in patients with adenoviral subepithelial infiltration by first removing the infiltrative stroma with a smile and implanting the same volume of fresh lenticule in the prepared stromal pocket.

NCT ID: NCT05115058 Enrolling by invitation - Presbyopia Clinical Trials

A New Successful Approach for Emmetropic Presbyopic Patients Using Intrastromal Pocket With Smile Module

Start date: June 1, 2016
Phase: N/A
Study type: Interventional

Presbyopia is physiological insufficiency of accommodation associated with the aging of the eye that results in progressively worsening ability to focus clearly on close objects.Though presbyopia is a normal change in our eyes as we age, it often is a significant and emotional event because it's a sign of aging that's impossible to ignore and difficult to hide. This defect is usually corrected by using glasses with bifocal power of suitable focal lengths. But some patients don't want to use glasses for correction. In our study purpose is to show that near vision improves and patient satisfaction increases by preparing an intrastromal pocket for emmetropic patients with near vision problems using the SMILE module.

NCT ID: NCT04987060 Active, not recruiting - Clinical trials for Irregular Astigmatism

Intrastromal Fresh Human Corneal Lenticule Implantation Using Smile Surgery for Treatment of Irregular Corneal Astigmatism After Penetrating Keratoplasty (New Approach)

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

The aim of the study is to present the effect of implanting intrastromal fresh corneal lenticule by SMILE surgery as a new method-approach to correct the corneal shape on purpose to reduce irregular astigmatism and increasing visual acuity after penetrating keratoplasty.

NCT ID: NCT04913623 Recruiting - Clinical trials for Arthroplasty Complications

Correlation of Intramedullary Pressure and Systemic Inflammatory Parameters in Cemented Femoral Stem

Start date: March 23, 2021
Phase:
Study type: Observational

The cemented femoral stem have impact on increase on systemic parameters. Evaluation of the level of histamine, C-reactive protein (CRP) and leukocytes formula, IL1b, TNF alpha, IL6 and the reflection of changes of these parameters in the intra-operative course of hip replacement.

NCT ID: NCT04848740 Enrolling by invitation - Clinical trials for Progressive Disease of Corneae

Human Fresh Corneal Lenticule Implantation Criteria in Progressive Corneal Disease Using Relex-Smile

Relex-Smile
Start date: February 1, 2018
Phase: N/A
Study type: Interventional

Stroma is a fibrous, tough, transparent and the thickest layer of the corneae. The stroma is composed of organised collagen, which maintains transparency. Keratocytes are located between the lamella collagen fibers and secrete an extracellular matrix, which includes collagen, proteoglycan, crystalline proteins to maintain corneal transparency.

NCT ID: NCT04793893 Enrolling by invitation - Refractive Errors Clinical Trials

Treatment of Residual Hypermetropic Refraction on Young Patients After LASIK Using Human Fresh Corneal Lenticule Implantation With ReLEX Smile Surgery

Relex-Smile
Start date: January 8, 2019
Phase: N/A
Study type: Interventional

LASIK (laser-assisted in situ keratomileusis) is a type of refractive surgery for correction of myopia, hyperopia and astigmatism. Yet approximately 30% of operated patients have symptoms like glare, halos, dry eyes and especially residual hypermetrop refractive errors. Residual hypermetrop refractive errors are difficult to treat surgically, the current treatment is Refractive Lens Implantation - risks are similar to those of cataract surgery (endophthalmitis, loss of accommodation, etc.)

NCT ID: NCT04712318 Enrolling by invitation - Myopia Clinical Trials

Treatment of Residual Refraction Errors 6 Months After Trifocal IOL Implantation With Relex-Smile

Start date: June 1, 2016
Phase: N/A
Study type: Interventional

Successful treatment of residual refraction 6 months after IOL Implantation with Relex-Smile.