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NCT ID: NCT05177393 Recruiting - Esophageal Cancer Clinical Trials

Treatment Outcomes of Esophageal Cancer

Start date: February 28, 2019
Study type: Observational

This study will be a carried out through a prospective observational cohort design in conjunction with researchers in the African Esophageal Cancer Consortium (AfrECC). The purpose of this research is to prospectively evaluate outcomes related to existing treatment strategies for esophageal cancer (EC) at participating sites within AfrECC.

NCT ID: NCT05157126 Not yet recruiting - Fracture Open Tibia Clinical Trials

Gentamicin Open Tibia Study

Start date: January 2022
Phase: Phase 4
Study type: Interventional

Local application of antibiotics directly to the traumatic wound is a promising treatment for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in low-income countries. This study aims to measure the effect of locally applied gentamicin on risk of infection for open tibial fractures in Tanzania. If proven effective, local gentamicin would be a highly cost-effective strategy to reduce complications and disability from open tibial fractures that could impact care in both high- and low-income countries.

NCT ID: NCT05154513 Recruiting - HIV Infection Clinical Trials

Long-Term Clinical, Immunologic, and Virologic Profiles of Children Who Received Early Treatment for HIV

Start date: December 15, 2021
Study type: Observational

IMPAACT 2028 is an observational prospective study to characterize a cohort of early treated children who may participate in future research related to HIV remission or cure. Up to approximately 250 participants will be in the study for approximately seven years. No intervention is provided in the study.

NCT ID: NCT05150808 Recruiting - Malaria,Falciparum Clinical Trials

Vectron T500 (Broflanilide 50WP) for IRS in Tanzania Tanzania

Start date: October 1, 2020
Phase: Phase 3
Study type: Interventional

Malaria is a major public health problem in Africa. An important way to control the disease is by Indoor Residual Spraying of insecticide in houses. Insecticide resistance has become a major problem. This trial will evaluate a novel insecticide against those insecticide resistant mosquito vectors in Tanzania E Africa.

NCT ID: NCT05144763 Recruiting - Child Health Clinical Trials

Dynamic CDSA to Manage Sick Children in Tanzania

Start date: December 1, 2021
Phase: N/A
Study type: Interventional

This study aims to reduce morbidity and mortality among children and mitigate antimicrobial resistance using a novel clinical decision support algorithm, enhanced with point-of-care technologies to help health workers in primary health care settings in Tanzania. Furthermore, the tool provides opportunities to improve supervision and mentorship of health workers and enhance disease surveillance and outbreak detection.

NCT ID: NCT05139524 Recruiting - Rift Valley Fever Clinical Trials

RVF and Other Emerging Infectious Diseases in East and Central Africa

Start date: October 8, 2021
Study type: Observational

Rift Valley fever (RVF), a disease transmitted from livestock (cattle, sheep, goats, camels) to humans more commonly occurs in the East and Central Africa (ECA) regions where more than 15 major epidemics affecting more than one country have been reported over the past 50 years. Within the region, there are specific areas, referred to as hotspots, which support RVF virus maintenance via low-level virus circulation between animals, humans, and mosquitoes. Most outbreaks originate from these hotspots. Our goal is to conduct studies in RVF hotspots in four ECA countries, Kenya, Uganda, Tanzania, and Democratic Republic of Congo (DRC) to determine the burden of RVF disease among humans, wildlife and livestock during inter-epidemic periods (IEPs) and discover circulation of undetected infectious diseases. This information is important for use in developing an early warning system and possibly a vaccination strategy. The study will take place in Uganda, Kenya, Tanzania and Democratic Republic of Congo

NCT ID: NCT05125133 Recruiting - Malaria,Falciparum Clinical Trials

Evaluation of Insecticide-treated Eave Nets and Window Screens for Malaria Control in Tanzania.

Start date: July 9, 2021
Phase: N/A
Study type: Interventional

This is a household randomized trial of a new tool for house modification, Insecticide-Treated Eave nets (ITENs) in combination with insecticide-treated window screens (ITWS), coated with a dual active ingredient (dual AI): Deltamethrin at 3g AI/kg, which corresponds to 144 mg/m² and PBO synergist at 10g/kg which corresponds to 480 mg/m², as used in the so-called dual-AI LLIN or "resistance breaking" nets for resistance malaria vector control. Four hundred and fifty (450) households with intact walls, opened eaves, and those without screens or nets on the windows in Chalinze district, Tanzania will be eligible and only recruited upon written informed consent. The households will be randomly allocated into two arms: one with ITENs and ITWS installed and the other without. The primary outcome will be malaria parasite detection in household residents aged over 6 months old using a quantitative Polymerase Chain Reaction (qPCR) at approximately 12 months post-installation, coinciding with the long rainy season.

NCT ID: NCT05033002 Not yet recruiting - HIV Clinical Trials

Efficacy Testing of a Culturally Relevant Stigma Intervention With WLWH in Tanzania

Start date: November 2021
Phase: N/A
Study type: Interventional

This study will test a stigma reduction intervention with women living with HIV in Tanzania.

NCT ID: NCT05028725 Not yet recruiting - Clinical trials for Esophageal Squamous Cell Carcinoma

Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma

Start date: March 1, 2022
Phase: N/A
Study type: Interventional

In the current protocol, we propose a study to evaluate a novel, combined esophageal sponge-methylation biomarker strategy for the early detection of esophageal squamous cell carcinoma (ESCC) as well as its precursor, esophageal squamous dysplasia (ESD). This strategy leverages the 'EsophaCap', a swallowable, retrievable sponge, with subsequent evaluation of the sample using a novel molecular biomarker assay. This biomarker assay evaluates methylation levels in three genes, which have been shown to differ significantly between ESCC cases and controls in pilot studies. Detection of methylation markers highly associated with ESCC could help identify patients with concurrent ESCC or at high risk of imminently developing this condition. If successful, this strategy could result in a paradigm shift for esophageal cancer control strategies in Tanzania and other high-incidence ESCC regions

NCT ID: NCT05017194 Recruiting - Hookworm Infections Clinical Trials

Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and Hookworm

Start date: August 15, 2021
Phase: Phase 2
Study type: Interventional

The rationale of the study is to provide evidence on the efficacy and safety of Emodepside in adults infected with Trichuris trichiura and hookworm.