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NCT ID: NCT04788862 Not yet recruiting - Malaria Clinical Trials

A Study of Blood-stage Controlled Human Plasmodium Falciparum Malaria Infection in Tanzania

Start date: August 1, 2021
Phase: N/A
Study type: Interventional

This will be a single-centre, open label trial to determine the safety and feasibility of CHMI model using Plasmodium falciparum-infected cryopreserved erythrocytes administered to healthy Tanzanian adults with varying prior exposure to P. falciparum.

NCT ID: NCT04788303 Not yet recruiting - Anemia Clinical Trials

Meals, Education, and Gardens for In-School Adolescents (MEGA) Project

MEGA
Start date: April 12, 2021
Phase: N/A
Study type: Interventional

This purpose of this study is to assess effects of a comprehensive, school-based nutrition intervention package on anemia status, anthropometric indicators, school performance/attendance, and development indicators among adolescents, and the knowledge, attitudes, and practices of nutrition, agriculture, and WASH among parents, in Tanzania.

NCT ID: NCT04781257 Recruiting - Tuberculosis Clinical Trials

Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries

ERASE-TB
Start date: March 2021
Phase:
Study type: Observational

The ERASE - TB study will be conducted in order to fill a critical unmet need for tuberculosis control. Persons who are in contact with an infectious TB case may become infected themselves. Among those who are infected, most will stay healthy but some will develop TB themselves. These people would benefit from preventive treatment, which would also stop TB from being spread to other persons. The problem currently is that it is impossible to determine with certainty who would require preventive treatment, and who will remain healthy. Out of 100 persons exposed to an infectious TB patient, only 2 will go on to have TB according to a study in Vietnam, but there are no good tests available to identify those with a risk for TB disease. Treating 100 persons to prevent 2 cases of TB is not effective, so preventive treatment is not used in adults and adolescents in Tanzania, Mozambique and Zimbabwe, where this study will be conducted, but also in many other settings. The ERASE - TB project will evaluate a number of newly developed diagnostic tests, to see which of those will be able to predict TB in persons at risk, and therefore steer preventive treatment well. For this, the investigators will invite 2,100 household contacts (HHC) of infectious TB patients, who are at least 10 years old, into the study. Everyone will be examined initially, and again in regular intervals, for 1.5 to 2 years; and whenever the participants will present with symptoms that could indicate that they develop TB. At every visit, the investigators will perform an X-ray and take some blood and urine samples to perform new candidate tests. At the first/baseline visit, all household contacts without TB will undergo a spirometry to evaluate their pulmonary function. If someone is unwell, the investigators will also examine sputum for the presence of TB bacilli. In the end, the investigators will then be able to say who of the persons in the study developed TB, and who remained healthy. From all samples taken at different timepoints, the investigators will then determine which test found TB early, and clearly distinguished between persons developing TB, and persons who would remain healthy .

NCT ID: NCT04602416 Completed - Violence, Physical Clinical Trials

Entrepreneurship and Beekeeping in Tanzania

Start date: April 24, 2015
Phase:
Study type: Observational

In Dar es Salaam, Tanzania (DSM) a pre-test post-test intervention pilot study with four arms was conducted. Each arm had 12-15 participants who were young men at risk for violence who were members of one 'camp'. Each participant was interviewed at baseline before the 4 camps were randomized. The interventions were training sessions in: Health (Control), Entrepreneurship, Beekeeping, and All Intervention sessions. Subsequent interviews took place 3 months, 6 months, and 1 year after all the interventions took place. This was a pilot study in preparation for a full intervention trial. The hypotheses for the intervention trial were expected to be that income would increase and violence would decrease in the intervention arms as compared to the Control arm.

NCT ID: NCT04565314 Active, not recruiting - Malnutrition Clinical Trials

ELICIT 2.0: Pilot Study of the Effect of Maternal Protein Supplementation During Lactation on Childhood Growth

Start date: November 12, 2019
Phase: N/A
Study type: Interventional

Haydom Global Health Research Center in north central Tanzania represents an important rural setting for performing high-quality medical research in sub-Saharan Africa. The region around Haydom is agricultural (predominantly maize-based), is resource-poor and has a high degree of stunting among local infants-with 70% stunting by 18 months in the MAL-ED study and 50% in the ELICIT study (for Early Life Interventions for Childhood Growth and Development In Tanzania). While the causes of this stunting are multifactorial, a potential contributor is early-life nutritional deficiencies, including inadequate dietary protein. One likely source of low protein delivery to infants is from low intake among area mothers during lactation, with potential effects on breast milk protein content and child weight gain. The current study is a pilot study assessing our study team's ability to successfully deliver protein-containing food products (a balanced-energy protein supplement) to lactating mother is in the area and assessing whether consumption of these food products improves childhood growth in the 1st year of life. This is a pilot study because of the potential difficulties in distributing these products on a large scale for daily consumption. As such, we aim to demonstrate an effective distribution network, a means of assessing adherence, and measuring endpoints while gathering knowledge regarding community acceptance. The current pilot project will evaluate the effectiveness of distribution and adherence on approximately 100 mother/child dyads. If effective, a future project could involve a large enough sample to be powered to detect reasonable changes in linear growth. . So, while the current proposal is not adequately powered to prove a hypothesis, the hypothesis underlying the study design is that daily protein supplementation delivered as a balanced protein product (Plumpy'mum) to lactating mothers for 3 months during the period from 0-6 months post-natal life will result in an increase in infant length-for-age Z-score (LAZ) by end of treatment. LAZ will be compared to controls from prior studies in the area.

NCT ID: NCT04550832 Not yet recruiting - Clinical trials for Pulmonary Tuberculosis

PanACEA DElpazolid Dose-finding and COmbination DEvelopment (DECODE)

DECODE
Start date: June 30, 2021
Phase: Phase 2
Study type: Interventional

This trial is to describe the safety, tolerability and exposure-toxicity relationship of Depazolid given over 16 weeks, in combination with standard-dose Bedaquiline, Delamanid and Moxifloxacin, compared to standard-dose Bedaquiline, Delamanid and Moxifloxacin alone

NCT ID: NCT04535011 Recruiting - Trauma Clinical Trials

PRACT to Investigate Controlling Alcohol Related Harms in a Low-Income Setting; Emergency Department BIs in Tanzania

PRACT
Start date: October 12, 2020
Phase: N/A
Study type: Interventional

Alcohol use is rapidly increasing in low- and middle-income countries, where it is inexpensive, readily available, poorly regulated, and there are few resources devoted to promoting safe alcohol use. A Brief Intervention based on a motivational interviewing framework has been shown to reduce alcohol use and alcohol-related harms. The investigators have translated and adapted a Brief Intervention for alcohol to the Tanzanian context and Swahili language called "Punguza Pombe Kwa Afya Yako (PPKAY)/ Reduce Alcohol for Your Health." This project will evaluate this intervention in injury patients presenting for care at the Kilimanjaro Christian Medical Center in Moshi, Tanzania. By using innovative adaptive clinical trial methods, the investigators will expedite the development of the most effective way to integrate this intervention into clinical care. By the end of this project, investigators will have identified the most effective brief intervention components and be able to characterize the intervention's effect overall. Additionally, investigators will standardize adaptive trial methods to revolutionize the science of clinical trials for behavioral sciences in low-resource settings.

NCT ID: NCT04529434 Not yet recruiting - Malaria Clinical Trials

Star Homes Project 2

SHP2
Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Malaria, pneumonia and diarrhoea causes a lot of illness in children in Tanzania and the study want to find better ways of protecting people against these diseases and want to find out if the type of house design can affect the general health of children living in the house.

NCT ID: NCT04517760 Completed - Clinical trials for Pediatric HIV Infection

Evaluating an HIV Risk Screening Tool for Orphans and Vulnerable Children in Tanzania

Start date: February 22, 2018
Phase:
Study type: Observational

The goal of the research was to evaluate the performance of items within the Kizazi Kipya (K2) Orphan and Vulnerable Children (OVC) HIV risk screening tool in identifying HIV-positive children, to optimize an HIV screening tool for OVC and children and adolescents in facility settings and to assess the feasibility and acceptability of home-based HIV risk screening and testing.

NCT ID: NCT04506918 Recruiting - Clinical trials for Surveys and Questionnaires

Comparison of SMS and IVR Surveys in Tanzania

Start date: October 23, 2020
Phase: N/A
Study type: Interventional

This study focuses on mechanisms to adapt the performance of interactive voice response (IVR) and short message service (SMS) surveys conducted in low-and middle-income (LMIC) setting (Tanzania) and evaluates how the two survey modalities (IVR and SMS) affect survey metrics, including response, completion and attrition rates.