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NCT ID: NCT03948867 Enrolling by invitation - Clinical trials for Sickle Cell Anemia in Children

Stroke Prevention With Hydroxyurea Enabled Through Research and Education (SPHERE)

Start date: April 24, 2019
Phase: Phase 2
Study type: Interventional

This study will 1) Evaluate the prevalence of elevated (conditional or abnormal) transcranial Doppler (TCD) velocities in a cross-sectional analysis of children with Sickle Cell Anemia (SCA) living in Tanzania; 2) Obtain longitudinal data on TCD velocities in this population; and 3) Measure the effects of hydroxyurea therapy on TCD velocities and associated primary stroke risk.