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NCT ID: NCT03930134 Completed - Clinical trials for Caesarean Scar Defect

Sparse Uterine Closure in Cesarean Section

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

The existence and the characteristics of a wedge- shaped defect in the uterine incision scar were demonstrated by radiologic, ultrasonographic, endoscopic and histologic methods by various authors. Cesarean scar defect is a deficient uterine scar or scar dehiscence following a cesarean section involving myometrial discontinuity at the site of a previous cesarean section scar. Cesarean scar defects may be associated with many clinical problems such as ectopicpregnancy at the cesarean section scar, rupture of the uterus during a subsequent pregnancy, dysmenorrhea and abnormal uterine bleeding during the non-pregnant state. These complications are likely to be associated with poor uterine scar healing following cesarean sections. Methods concerning closure of the uterine incision need to be considered with regards to benefit and potential harm in order to offer the best available surgical care to women undergoing cesarean section. Sur-gical suturing technique and mechanical tension affecting the surgical wound are the most important factors related to the incisional integrity. For this reason, investigators designed this prospective clinical study to analyze the effects of two different uterine suturing techniques. their aim was to compare the sparse closure of the uterine incision to classical one layer closure regarding short , mid and long term results. In deed, they compared : - duration of surgery and calculated blood loss during surgery as short term results - incidence of postoperative defective healing of the uterine incision , thickness of the ultrasound imaged uterine scar as mid-term results . - Incomplete uterine rupture, morbidly placental adhesion during subsequent pregnancy of these patients as long-term results.

NCT ID: NCT03928795 Completed - Perinatal Morbidity Clinical Trials

Perinatal Morbidity Factors During Cesarean Section

Start date: August 27, 2018
Phase:
Study type: Observational [Patient Registry]

Caesarean section is one of the most common surgeries in the world and the increasing rate of cesarean delivery is associated with increased maternal and fetal morbidity when compared to vaginal delivery. With this dramatic increase in caesarean section rates, it is urgent to identify factors that may affect perinatal morbidity. Indeed, such factors can be classified into: - Modifiable factors: surgical technique, anesthesia technique, operator experience, operative time - Not modifiable factors: characteristics inherent to the mother: BMI, gravidic pathology, number of caesareans... Majority of previous studies focused on anesthetic factors. A global vision integrating all parameters is necessary in order to best guide the preventative measures to be put in place. our Objectives were : To Identify and to Analyze Perinatal Morbidity Factors During Caesarean Section

NCT ID: NCT03886246 Active, not recruiting - Clinical trials for Generalized Pustular Psoriasis

Effisayilâ„¢ ON: A Study to Test Long-term Treatment With Spesolimab in People With Generalized Pustular Psoriasis Who Took Part in a Previous Study

Start date: May 27, 2019
Phase: Phase 2
Study type: Interventional

This study is open to people with generalized pustular psoriasis (GPP). People can only take part if they have completed treatment in a previous study with spesolimab (1368-0013 or 1368-0027). The goal of this study is to find out how well people with GPP tolerate long-term treatment with spesolimab. The study also tests whether spesolimab helps improve GPP symptoms and how quickly the symptoms improve after a flare-up. Every participant gets spesolimab for almost 5 years (252 weeks). Depending on their symptoms and whether they had a GPP flare during the previous trial, they get spesolimab every few weeks. When participants have a GPP flare during this trial, they get spesolimab as an infusion into a vein. Participants visit their doctors regularly. During these visits, the doctors collect information on any health problems of the participants. To assess the study endpoints, doctors regularly check participants' skin.

NCT ID: NCT03879954 Completed - Clinical trials for Central Venous Catheter

US-guided OOP Internal Jugular Vein Vs IP Supraclavicular Subclavian Vein Catheterization in ICU

IPSSCVC
Start date: February 26, 2019
Phase: N/A
Study type: Interventional

Patients were randomly divided into two groups: ultrasound-guided (US-guided) out-of-plane internal jugular vein (OOP-IJV) and in-plane supraclavicular subclavian vein (IP-SSV) catheterization. For OOP-IJV cannulation, the transducer was placed to identify IJV in short-axis view. The needle was introduced at an angle of 60° to the skin surface, and advanced under real-time US guidance until visualizing the tip of the needle inside the vein. For IP-SSV cannulation, a short-axis view of the IJV was obtained first. The probe was slid caudally following the IJV until getting the best long-axis view of the SCV. Using an in-plane approach, the needle was inserted at the base of the transducer at a 30° angle and advanced under the long axis under real-time US guidance targeting the SCV.

NCT ID: NCT03875586 Completed - Clinical trials for Evaluate the Reasons for Consultation in Family Medicine

Consultation Reasons in Family Medicine

EMOCONSULT
Start date: April 29, 2019
Phase:
Study type: Observational

The Tunisian society of family medicine STMF proposes to coordinate a national, observational, transversal and multicenter survey, at the consultations of general medicine / family medicine.

NCT ID: NCT03870763 Terminated - Clinical trials for Multiple Sclerosis, Relapsing-Remitting

Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and Peginterferon Beta-1a (Plegridy) for the Treatment of Relapsing-Remitting Multiple Sclerosis in Pediatric Participants

Start date: March 19, 2019
Phase: Phase 3
Study type: Interventional

The main objective of the study is to evaluate the efficacy of dimethyl fumarate (Tecfidera) and peginterferon beta-1a (Plegridy), both compared with placebo, in pediatric participants with RRMS. The other objectives of this study are to evaluate the safety and tolerability of dimethyl fumarate and peginterferon beta-1a and to assess the effect of dimethyl fumarate and peginterferon beta-1a, both compared with placebo, on additional clinical and radiological measures of disease activity.

NCT ID: NCT03863756 Active, not recruiting - Spondyloarthritis Clinical Trials

Performance of EOS Imaging System in the Assessment of Spondyloarthritis Structural Changes Compared With Standard Radiography

Start date: January 1, 2018
Phase:
Study type: Observational

Spondyloarthritis is a chronic rheumatic disease that requires prolonged radiographic follow-up. This repetitive exposure to ionizing radiation puts at risk the radiosensitive organs exposed in the field of irradiation. A new low-dose imaging system has emerged. This technique, called EOS, offers the advantage of lower irradiation associated with high images quality. Our goal through this work was to evaluate the reliability of the EOS imaging system compared to conventional radiography in the evaluation of the structural damage of SpA.

NCT ID: NCT03853174 Completed - COPD Clinical Trials

Exercise Training and Inflammatory Mediators in COPD

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020[1]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable[2].

NCT ID: NCT03831204 Completed - Heart Failure Clinical Trials

Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF)

Start date: February 20, 2017
Phase:
Study type: Observational

The performance of STIs and clinical scores alone and their combination to predict short term prognosis of acute decompensated heart failure.

NCT ID: NCT03830359 Completed - Dry Eye Syndrome Clinical Trials

Efficacy, Safety of T2769 in Dry Eye Disease

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

Efficacy of T2769 in Dry Eye Desease