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NCT ID: NCT05251259 Recruiting - Asthma Clinical Trials

Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma

FLASH
Start date: January 27, 2022
Phase: Phase 2
Study type: Interventional

This is a randomised, placebo-controlled, double-blind study to assess the efficacy and safety of Atuliflapon administered once daily over a 12-week treatment period to adult participants with moderate to severe uncontrolled asthma.

NCT ID: NCT05248152 Recruiting - Postoperative Pain Clinical Trials

Effect of Psychosocial and Psychophysical Factors and Preemptive Analgesia on Postoperative Pain in Upper Limb Surgery

Start date: January 13, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to define the role of preemptive systemic analgesia in combination with regional anesthetic techniques on postoperative pain following upper limb surgery in different subgroups of patients with different psychosocial and psychophysical characteristics.

NCT ID: NCT05247424 Recruiting - Clinical trials for STEMI - ST Elevation Myocardial Infarction

Pretreatment With Unfractionated Heparin for ST Elevation Myocardial Infarction

UFH-STEMI
Start date: March 10, 2022
Phase: Phase 4
Study type: Interventional

Rupture of a coronary artery plaque leads to thrombotic occlusion of the coronary artery and would present as ST segment elevation myocardial infarction. Early treatment with aspirin and early primary percutaneous coronary intervention are indicated. Anticoagulation therapy, usually with unfractionated heparin, is required during percutaneous coronary intervention. Investigators hypothesis is that pretreatment with unfractionated heparin in addition to aspirin at first medical contact may facilitate spontaneous reperfusion of culprit artery and procedural thrombotic complication in patients with ST elevation myocardial infarction without significant risk of bleeding complications.

NCT ID: NCT05242484 Recruiting - Colitis, Ulcerative Clinical Trials

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis

DUET-UC
Start date: September 19, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of JNJ-78934804 as compared to guselkumab and golimumab in participants with moderately to severely active ulcerative colitis who have had an inadequate initial response, loss of response, or intolerance to one or more approved advanced therapy.

NCT ID: NCT05242471 Recruiting - Crohn's Disease Clinical Trials

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease

DUET-CD
Start date: July 22, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy of JNJ-78934804 at Week 48 compared to guselkumab and golimumab.

NCT ID: NCT05221450 Recruiting - Clinical trials for Apical Periodontitis

Factors Affecting the Endodontic Treatment Outcome

Start date: January 1, 2008
Phase:
Study type: Observational

The aim of this prospective cohort observational study is: (i) to assess the endodontic treatment outcome in a private specialist endodontic office in Slovenia; (ii) to estimate the effect of various pre-, intra- and postoperative factors onto endodontic treatment outcome.

NCT ID: NCT05218278 Recruiting - Clinical trials for Out-Of-Hospital Cardiac Arrest

NFL Dynamics as a Predictor Factor in Patients With Out of Hospital Cardiac Arrest

Start date: January 1, 2022
Phase:
Study type: Observational

To investigate the pharmacodynamics of light chain of NFL in patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.

NCT ID: NCT05193994 Recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

Triumeq in Amyotrophic Lateral Sclerosis

LIGHTHOUSE II
Start date: February 24, 2022
Phase: Phase 3
Study type: Interventional

To determine if Triumeq improves survival in Amyotrophic Lateral Sclerosis (ALS) compared with placebo

NCT ID: NCT05156281 Recruiting - Clinical trials for Relapsing Multiple Sclerosis

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

REMODEL-2
Start date: December 13, 2021
Phase: Phase 3
Study type: Interventional

To compare the efficacy and safety of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis (RMS)

NCT ID: NCT05150704 Recruiting - Myocarditis Acute Clinical Trials

MYTHS - MYocarditis THerapy With Steroids

MYTHS
Start date: October 7, 2021
Phase: Phase 3
Study type: Interventional

This is a phase III, multi-center international, single blind randomized controlled trial to test the efficacy of pulsed intravenous (IV) methylprednisolone versus standard therapy on top of maximal support in patients with Acute myocarditis (AM).