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NCT ID: NCT03912441 Completed - Healthy Clinical Trials

First-In-Human Study to Evaluate Safety And Pharmacokinetics of Single Escalating Doses of BCD-147 (Bispecific Anti-HER2/HER2 Antibody) in Healthy Subjects

Start date: January 30, 2019
Phase: Phase 1
Study type: Interventional

This is an open-label, phase 1, "3+3 trial" of pharmacokinetics, safety and immunogenicity of BCD-147 (JSC "BIOCAD", Russia) after single administration of escalating doses in healthy male volunteers

NCT ID: NCT03909165 Completed - Clinical trials for Neuromuscular Blockade

Efficacy, Safety, and Pharmacokinetics of Sugammadex (MK-8616) for Reversal of Neuromuscular Blockade in Pediatric Participants Aged Birth to <2 Years (MK-8616-169)

Start date: July 23, 2019
Phase: Phase 4
Study type: Interventional

This study will evaluate the efficacy, safety, and pharmacokinetics (PK) of sugammadex (MK-8616) for reversal of both moderate and deep neuromuscular blockade (NMB) in pediatric participants aged birth to <2 years. The primary hypothesis of this study is that sugammadex is superior to neostigmine in reversing moderate NMB as measured by time to neuromuscular recovery.

NCT ID: NCT03908216 Completed - Clinical trials for Overweight and Obesity

Evaluation of Non-pharmacological and Pharmacological Treatment for oVerweight and Obesity in pAtients of the Outpatient Register (EVA)

EVA
Start date: April 18, 2019
Phase:
Study type: Observational

A prospective non-interventional single-centre study aimed to assess the current practice of non-pharmacological treatment and pharmacological therapy of overweight and obesity in patients with cardiovascular diseases (CVD) or with a high risk of CVD according to the patients' survey data

NCT ID: NCT03906734 Completed - Clinical trials for Hypertrophic Cardiomyopathy

Mitral Valve Management During Septal Myectomy

MVMSM
Start date: January 10, 2016
Phase: N/A
Study type: Interventional

Objective of the study: to evaluate whether alfieri technique improves clinical and hemodynamic results compared to transaortic mitral valve secondary cord cutting in patients scheduled to septal myectomy for severely symptomatic hypertrophic obstructive cardiomyopathy.

NCT ID: NCT03905525 Completed - Sjögren Syndrome Clinical Trials

Study of Safety and Efficacy of Multiple Doses of CFZ533 in Two Distinct Populations of Patients With Sjogren's Syndrome

TWINSS
Start date: October 1, 2019
Phase: Phase 2
Study type: Interventional

This study will evaluate safety, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple doses of CFZ533 (iscalimab) in patients with Sjögren's Syndrome.

NCT ID: NCT03901391 Completed - Clinical trials for Retinitis Pigmentosa

Prospective Open Clinical and Genetic Study of Patients With Retinitis Pigmentosa

RU-RP
Start date: March 26, 2019
Phase:
Study type: Observational

This study is aimed to characterize Russian population of Retinitis Pigmentosa

NCT ID: NCT03900234 Completed - Clinical trials for Chronic Venous Insufficiency

Prevalence of Chronic Venous Disease in General Population

Start date: July 1, 2015
Phase:
Study type: Observational

This study is designed to find prevalence and risk factors for chronic venous disease (CVD) in the general population. All the resident, who live in a single rural settlement will be invited to participate.

NCT ID: NCT03898193 Completed - Healthy Adults Clinical Trials

Bioequivalence Study of Montelukast, 5 mg Chewable Tablets (Pharmtechnology LLC, Belarus), and Singulair®, 5 mg Chewable Tablets (Merck Sharp & Dohme B.V., the Netherlands), in Healthy Volunteers Under Fasting Conditions

Start date: March 23, 2019
Phase: Phase 1
Study type: Interventional

This is an open-label, randomized, single-center, single-dose, crossover, in two periods and in two sequences comparative study, where each participant is randomly assigned to the reference or the test formulation in each period of the study (sequences Test-Reference (TR) or Reference-Test (RT)), in order to evaluate if both formulations are bioequivalent.

NCT ID: NCT03898011 Completed - Healthy Adults Clinical Trials

A Bioequivalence Study of Two Formulations Lamotrigine 100 mg Tablets and Lamictal 100 mg Tablets in Healthy Adult Volunteers Under Fasting Conditions

Start date: March 23, 2019
Phase: Phase 1
Study type: Interventional

This is an open-labeled, randomized, crossover, two-period, single-center, comparative study, where each participant will be randomly assigned to the reference (Lamictal, 100 mg tablets) or the test (Lamotrigine, 100 mg tablets) formulation in each period of study (sequences Test-Reference (TR) or Reference-Test (RT)), in order to evaluate if both formulations are bioequivalent

NCT ID: NCT03897738 Completed - Clinical trials for Perimenopause, Climacteric Syndrome

Clinical Evaluation of Effectiveness and Safety of Amberen and Smart B in Perimenopausal Women.

Start date: April 30, 2019
Phase: N/A
Study type: Interventional

To evaluate effectiveness and safety of combined use of dietary supplements Amberen and Smart B in women with a typical (without complications) form of climacteric syndrome, with mild to moderate symptoms in perimenopause.