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NCT ID: NCT05099289 Recruiting - Clinical trials for Ventricular Tachycardia

Parasternal Access for Substernal Shocks and Pacing With an acUtely Placed Less-invasive Lead for EV-ICD (PASS PULL EV-ICD) Study

PASS PULL
Start date: November 17, 2021
Phase: N/A
Study type: Interventional

The PASS PULL Study is a prospective, multi-center, single-arm study without concurrent or historical controls. This initial concept feasibility study is primarily intended to demonstrate that the EV-ICD Lead can be safely positioned within the anterior mediastinum as intended using the AtaCor delivery system. The study will secondarily characterize the ability for the EV-ICD Lead to facilitate VF sensing and defibrillation.

NCT ID: NCT05011526 Active, not recruiting - Covid19 Vaccine Clinical Trials

A Study to Evaluate Immunogenicity and Safety of MVC-COV1901 Compared With AZD1222 Against COVID-19 in Adults

Start date: October 8, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the immunogenicity and safety of MVC-COV1901 vaccine compared to AZD1222 in heathy adults.

NCT ID: NCT04905966 Completed - Childhood Obesity Clinical Trials

Effect of a Physical Activity and Nutrition Education Intervention on Obesity Prevalence in Schoolchildren

Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Childhood obesity is a major global public health problem. Several strategies have been implemented to reduce the high prevalence, the most cost-effective of which were those that focused on the school environment. Although there is vast research that focus on interventions that address obesity through interventions to improve schoolchildren diets and physical activity level in many countries of the Latin American region, there is lack of evidence of the effectiveness of multicomponent interventions that aim to reduce the prevalence of obesity among schoolchildren in the Paraguayan context.

NCT ID: NCT04905511 Recruiting - Clinical trials for End Stage Renal Disease

Preliminary Safety of The TRUE Vascular Graft for Hemodialysis Access (TRUE HD I Study)

Start date: May 10, 2021
Phase: Phase 1
Study type: Interventional

Prospective, nonrandomized, single-arm, single-center, open-label, first-in-human clinical study in subjects with end-stage renal disease (ESRD) and not candidates for an autogenous fistula creation.

NCT ID: NCT04864652 Recruiting - Clinical trials for Obstructive Sleep Apnea of Adult

Safety and Dosing Study of the CHILLS Cryotherapy for the Treatment of OSA

ARCTIC-1
Start date: November 30, 2020
Phase: N/A
Study type: Interventional

ARCTIC-1 is a safety and dosing study to evaluate procedure tolerability in patients with clinically diagnosed moderate or severe OSA.

NCT ID: NCT04834115 Recruiting - Covid19 Clinical Trials

Efficacy of Ivermectin in Outpatients With Non-severe COVID-19

Start date: November 17, 2020
Phase: Phase 3
Study type: Interventional

This is a randomized controlled trial to evaluate the efficacy of ivermectin in reducing the risk of progression to severe disease and hospitalizations in COVID-19 patients.

NCT ID: NCT04809701 Enrolling by invitation - Clinical trials for Ventricular Arrythmia

Non-vascular ICD Electrode Configuration Feasibility Study

Start date: March 22, 2021
Phase: N/A
Study type: Interventional

This study is designed to evaluate the energy requirements of two different Nonvascular ICD (NV-ICD) electrode configurations for achieving successful defibrillation of ventricular arrhythmias.

NCT ID: NCT04783779 Recruiting - Clinical trials for End Stage Renal Disease

Evaluation of STARgraft-2 for Hemodialysis Access

Start date: February 16, 2021
Phase: N/A
Study type: Interventional

This study is a single site, prospective, single arm evaluation of the safety and effectiveness of the Healionics STARgraft-2 hemodialysis access graft. STARgraft devices have been demonstrated in preclinical and other studies to have improved resistance to the common failure modes of venous anastomosis stenosis and infection. This study is an extension from a prior First in Human (FIH) study (NCT03916731) with the STARgraft AV investigational device. That study also included control implants of commercially available standard ePTFE grafts approved for the same use. The study is enrolling patients with End Stage Renal Disease (ESRD) requiring hemodialysis via a prosthetic vascular graft. The study proposes to: 1. Evaluate the performance of the investigational STARgraft-2 compared to the ePTFE controls in the prior study and to published results, over a period of 6 months, with extended results to 1 year. 2. Verify safety of the STARgraft-2 multilayer construction in extended dialysis vascular access use. It is intended to enroll 25 subjects in this study.

NCT ID: NCT04768231 Not yet recruiting - Tuberculosis Clinical Trials

Rifampicin at High Dose for Difficult-to-Treat Tuberculosis

RIAlta
Start date: April 1, 2021
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety of rifampicin given at a dose three times as the standard one, in persons with tuberculosis that belong to groups that have not been widely included in previous trials.

NCT ID: NCT04747158 Completed - Clinical trials for SARS-CoV-2 Infection

COVID-19 Convalescent Plasma Therapy

TPCC
Start date: August 10, 2020
Phase: Phase 2/Phase 3
Study type: Interventional

This study is an open-label trial in which hospitalized patients with risk factors of severe coronavirus disease 2019 [COVID-19] will be receive treatment with convalescent plasma (≤ 15 days from symptoms start).