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NCT ID: NCT04185935 Recruiting - Malignant Neoplasm Clinical Trials

Molecular Genetics Studies of Cancer Patients and Their Relatives

Start date: April 18, 1997
Phase:
Study type: Observational

This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.

NCT ID: NCT04181970 Recruiting - Clinical trials for Gastrointestinal Stromal Tumors

Observational Study, for Quality Assessment, of Sarcoma in European and Latin American Multidisciplinary NETWORK

(SELNET)
Start date: June 30, 2019
Phase:
Study type: Observational [Patient Registry]

Post-authorisation, multicentric, observational, retrospective and prospective study to assess quality of care of sarcoma patients in expert and non-expert centers by analysing correlation of quality items and outcomes such as relapse free survival, overall survival, percentage of amputation, etc. Expert pathology peer review will be performed to detect differences between expert and non-expert centers as well as differences in treatment and patient prognosis. Tumor samples of 4 types of sarcoma would also be included in translational research to detect biomarkers and produce preclinical models.

NCT ID: NCT04181762 Terminated - Lupus Nephritis Clinical Trials

Study of Safety, Efficacy and Tolerability of Secukinumab Versus Placebo, in Combination With SoC Therapy, in Patients With Active Lupus Nephritis

SELUNE
Start date: July 7, 2020
Phase: Phase 3
Study type: Interventional

The purpose of this trial is to evaluate the efficacy and safety of subcutaneous secukinumab 300 mg compared to placebo, in combination with standard of care therapy (SoC), in subjects with active lupus nephritis (ISN/RPS Class III or IV, with or without co-existing class V features).

NCT ID: NCT04177108 Completed - Clinical trials for Triple-Negative Breast Cancer

A Study of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Locally Advanced or Metastatic Triple-Negative Breast Cancer

Start date: November 25, 2019
Phase: Phase 3
Study type: Interventional

This study evaluated the efficacy and safety of ipatasertib in combination with atezolizumab and paclitaxel in locally advanced or metastatic Triple-Negative Breast Cancer (TNBC) previously untreated in this setting.

NCT ID: NCT04173806 Recruiting - Telemedicine Clinical Trials

Evaluation of an Online Telemedicine Course Through Facebook

Start date: November 25, 2019
Phase: N/A
Study type: Interventional

Health professionals with adequate training are required to provide quality remote care. There are few telemedicine and telehealth training programs for doctors and medical students. On the other hand, the use of social networks (Facebook and Twitter) as a medical education tool is becoming frequent. However, there is a lack of conclusive evidence in terms of its effectiveness. The objective of the present study is to develop and evaluate a telemedicine course for resident doctors through Facebook and compare it with one through Moodle. A randomized, triple-blind, parallel block controlled trial will be conducted that tests the effectiveness of an educational intervention through Facebook compared to another control intervention using Moodle. Intervention training is a telemedicine course focused on teleconsultation provided through Facebook. Control training is the same educational content but through Moodle. The level of telemedicine knowledge of the participants before and after the intervention will be evaluated. The inferential analysis to see the association between the variables of interest will be carried out by Student's T tests or analysis of variance (ANOVA). If potential confounding factors were found, the variable will be adjusted through linear regression. The pre and post intervention analysis will be carried out with student t or wilcoxon rank test according to the normality of the data. Resident doctors who receive the telemedicine course through Facebook are expected to have a greater knowledge gain than those who take the course through Moodle.

NCT ID: NCT04170543 Completed - Clinical trials for Diabetic Kidney Disease

A Phase 2b Diabetic Kidney Disease Study

Start date: November 18, 2019
Phase: Phase 2
Study type: Interventional

A Phase 2b Randomized, Double-blind, Placebo-controlled, Study to Evaluate the Efficacy and Safety of MEDI3506 in Subjects with Diabetic Kidney Disease

NCT ID: NCT04159415 Active, not recruiting - Clinical trials for Generalized Lipodystrophy

Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized Lipodystrophy

Start date: January 7, 2020
Phase: Phase 2
Study type: Interventional

The primary objectives of the study are to estimate the effects of REGN4461 on glycemic parameters in the subset of patients with elevated baseline hemoglobin A1c levels (HbA1c ≥7%) and to estimate the effects of REGN4461 on fasting triglyceride levels in the subset of patients with elevated baseline fasting triglycerides (TG ≥250 mg/dL). The secondary objectives are to estimate the effects of REGN4461 on a composite endpoint of changes in either HbA1c or fasting TG for all patients, estimate the effects of 3 dose levels of REGN4461 on glycemic parameters and fasting TG, to estimate the effects of REGN4461 on insulin sensitivity, to evaluate the safety and tolerability of REGN4461 and to evaluate the pharmacokinetics (PK) and immunogenicity of REGN4461.

NCT ID: NCT04158258 Active, not recruiting - Breast Cancer Clinical Trials

A Study to Describe the Diagnosis, Anti-Cancer Treatment and Clinical Outcome in Patients With Newly Diagnosed Breast Cancer in Latin America

Start date: February 21, 2020
Phase:
Study type: Observational

A Prospective, Multicenter, Non-Interventional Study of Primary Data Collection, Designed to Describe the Diagnosis, Anti-Cancer Treatment and Clinical Outcomes in Patients with Breast Cancer in Latin America.

NCT ID: NCT04157231 Not yet recruiting - Acute Stroke Clinical Trials

Essential Acute Stroke Care in Low Resource Settings: a Pilot studY

EASY
Start date: October 30, 2024
Phase: N/A
Study type: Interventional

An investigator-initiated, evaluator-blinded, prospective, multi centre, before-and-after, effectiveness-implementation hybrid design study to assess the feasibility of essential acute stroke care in a low resource setting

NCT ID: NCT04153149 Active, not recruiting - Clinical trials for Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Start date: November 26, 2019
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of vutrisiran 25 mg administered subcutaneously (SC) once every 3 months (q3M) compared to placebo in patients with ATTR amyloidosis with cardiomyopathy.